summary2018

J.EXPERIMENTAL & CLINICAL MEDICINE

2019, № 3

1. R.G.KVERENCHKHILADZE

ECOTOURISM - AN IMPORTANT DIRECTION OF THE GEORGIAN ECONOMY AND HEALTHCARE

TSMU, The Department of Environmental Health and Occupational Medicine, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-9-11.

Ensuring a healthy ecological environment, along with the medical problem, is driven by important economic preconditions. Ecologically favorable environment forms an important prerequisite for the development of tourism, in particular for the development of ecotourism. Georgia has great potential for developing an ecotourism, which involves an important economic resource. Widely usage of tourism for ecological purposes in Georgia has significant economical and health potential, which will play an essential role in maintaining and strengthening the population health, improving the ecological situation and advancing the economy of the country and its various regions.

2. I.MCHEDLISHVILI, G.BAIDOSHVILI, R.CHOCHISHVILI, D.GELOVANI

TRENDS OF HEPATITIS C IN GEORGIA

Department of Epidemiology and Biostatistics, Tbilisi State Medical University, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-11-13.

Trends of hepatitis C during 2011-2018 years were investigated in Georgia. Since 2015 the incidence of this infection has been increasing dramatically: in 2011 incidence rate per 100,000 population was 65.5, while in 2018 it achieved 229.9. In addition, the proportion of Hepatitis C incidence has been increased among new cases of viral hepatitis; in 2018 it was 81.3%. The increased incidence of Hepatitis C is most likely related to significantly improved detection of new cases.

3. N.CHKHAIDZE, M.GIORGOBIANI, N.CHIGOGIDZE, Z.CHEKURASHVILI, G.IAKOBASHVILI, B.ZURASHVILI.

OUTCOME OF THE EPIDEMIOLOGICAL‘SURVEY TO MEASURE THE INFLUENCE OF THE PESTICIDES AGAINST BROWN MARMORATED STINK BUG ON THE HUMAN HEALTH OF INHABITANTS OF ACTION AREAL (IMERETI REGION)

N. Makhviladze S/R Institute of Labor Medicine add Ecology, Tbilisi State Medical University, Hygiene and Medical Ecology Department, LTD ,,Agrokartly”, National Food Agency.Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-13-16.

Bifenthrin (from Pyretroid chemical compound group) containing pesticides are used to fight Brown marmorated stink bug in Georgia. In order to study possible impact of these substances on the human health condition, descriptive epidemiological survey was made among inhabitants of the pesticides action area. The survey polled 105 inhabitants.

After survey results analysis, it was detected, that in many cases, respondents who had contact with above mentioned pesticides suffered from various complaints, which were provoked by these pesticides. People who had complaints have following diagnoses: dermatitis, allergy, goiter, diabetes, heart failure, eye disease, pneumonia, hypertonic, kidney diseases,.While, they complained on the following dizziness, shortness of breath, skin atching, eye aiching, muscle shivering, flaccidity, enhanced coughing, headache, vomiting, diarrhea.

If should be took into consideration, that because of the negligence, one of the respondents had light poisoning from the pesdicides. Unfortunately, sometimes chemical treatment is held without prior notice.

4. SEVDA NEJADI

ECOTOURISM & HOT SPRINGS IN CAUCASUS CONCENTRATED ON GEORGIA & IRAN

Master of Tourism Management - Marketing

J. Experimental and Clinical Medicine, 2019, 3, pp-16-19.

Ecotourism is considered to be as a natural environment contribution by travelers. Ecotourism typically involve travel to destinations where natural, unique pristineareas with cultural heritage. Ecotourism has a strong emphasis on education, sustainability, awareness and nature conservation.

In this case we studied the geothermal ecosystem of two countries which both are in Caucasus area. Georgia and Iran, have good potential of ecotourism in field of hot springs with high therapeutic prospect. However, due to lack of management, marketing and publicity they are not well introduced worldwide, and so far are not counted as ecotourism destinations for their Hot Springs and therapy potentials.Hence, they have not enough and appropriate health care and welfare facilities.

5. NASSER ELAHI

THE ROLE OF HSE IN OCCUPATIONAL HEALTH AND PREVENTING ACCIDENTS

Retire from College of Engineering, of (SCU) & (KMSU) and Founder & Chairman of (ISSA), (IFPSAU), & (RIISHW) & Mrs. Jaleh B. Akbari, agent of ISSA in Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-19-21.

Since last few decades while the industry is amazingly prospering towards modern technology, it entailed complicated production techniques inherently associated with many dangers.

The inadequate dissemination of knowledge and information hampers action, especially in developing countries. It also limits the capacity to design and implement effective policies and programmers. To reduce the human suffering and financial loss associated with these risks, there is a need for increased and sustained action to protect occupational health and safety, and the environment, as HSE roles and plan.

6. 1,2T.ZURASHVILI, 2B.ZURASHVILI

FACTORS ASSOCIATED WITH HIV RISKY SEXUAL BEHAVIOR AMONG TBILISI

18-24 YEARS OLD UNIVERSITY STUDENTS

1Georgian Harm Reduction Network; 2Tbilisi State Medical University, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-21-27.

Aim: To examine possible associations between socio-demographic, unhealthy life-style factors and risky sexual behavior in Georgian students.

Methods: We conducted the secondary analysis of Youth Behavioral Surveillance Survey conducted in 2011 among secondary and post-secondary school students in Tbilisi. The current analysis was limited to those participants who indicated that they had sexual activity during the last 12 months (n=397). We conducted appropriate recoding and created variables of interest followed by statistical analyses using SPSS-16.

Results: Three hundred and six (77.1%) of respondents reported having unsafe sexual intercourse in the pasts 12 months. In the multivariate regression model, significant predictors of risky sexual behaviors in the past 12 months experience included being male (OR=0.03; 95% CI 0.01-0.027;p=0.002), past 12-month ecstasy use (OR=18.9; 95% CI 1.15-313.3;p=0.040) and more often going out in the evenings (OR=1.9; 95% CI 1.05-3.27;p=0.034).

Conclusions: The study suggests the need for more research regarding correlates of risky behaviors and provides important basis for developing recommendations for relevant collaborators to reduce HIV risk behaviors among youth in Georgia.

7. B.Kurashvili, C.Siprashvili, E.Bobokhidze

FOOD ALLERGY IN CHILDREN AND ADOLESCENTS

TSMU, Department of Nutrition and Age MedicineK

J. Experimental and Clinical Medicine, 2019, 3, pp-27-30.

Prevalence of food allergy is increasing all over the world every year. 1-5% of whole population has any kind of food allergy during their life time. Mostly infants and preschool toddlers are suffering from this state. In order to analyze the prevalence of food allergy in Georgia, the study was done one of the biggest allergy centers in Tbilisi “Allergy XXI Century”. According to 239 patients’ histories, data was analyzed in statistical analysis program. The results showed, that during last 4 years 149 skin dermatitis, 67 allergic dermatitis, 12 urticaria, 8 atopic dermatitis diagnosis have been made. Statistical analysis showed that the numbers have been increasing every year. Further research needs to be done in order to analyze the data all over the country.

8. F.V.JAPARIDZE, M.S.BAKRADZE, N.O.SHONIA, L.R.JAPARIDZE, S.R.GVARISHVILI

EPIDEMIOLOGY OF DENTAL CARIES AND FEATURES OF DENTAL CARE AMONG SCHOOLCHILDREN OF THE ADJARA REGION

Batumi Shota Rustaveli State University, Department of Stomatology;

TSMU Departament of Orthopedic Stomatology and Maxillo- Facial Surjery, Ceorgia

J. Experimental and Clinical Medicine, 2019, 3, pp-30-35.

557 children were examined. 308 pupils of schools of the municipalities of mountainous Adjara (Khulo, Shuakhevi, and Keda) and 249 pupils of schools of Kobuleti and Khelvachauri municipalities. Age of pupils was the following: 6-7, 12, 15 years old. The selection was made according to the recommendations of the World Health Organization (WHO). The spread and intensity of caries were determined, also was calculated the volume of the dental care by municipalities.

The research has revealed:

1. The caries prevalence rate in all age groups is high, the rate of caries intensity is also high compared to the data set for Georgia.

2. The amount of dental care in the surveyed municipalities is very insufficient and filling out dental offices with appropriate specialists is needed.

9. M.TSIMAKURIDZE, MAIA TSIMAKURIDZE, D.ZURASHVILI,

N.KHACHAPURIDZE, E.MAISURADZE

MODERN ASPECTS OF OCCUPATIONAL REHABILITATION

TSMU, Department of Environmental Health and Occupational Medicine, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-38-38.

Changes in immunological status of patients with occupational intoxication by manganese have been identified. These peculiarities may be used for early diagnosis of mangmanism.

Several perspective scientific research methodologies have to be established in order to prevent different forms of severe occupational intoxication caused by manganese.

10. L.BAKRADZE, G.KVERENCHKHILADZE, S.KVERENCHKHILADZE, MAIA TSIMAKURIDZE, N.KHACHAPURIDZE, N.KHUNASHVILI, K.MURJIKNELI

HYGIENIC CHARACTERIZATION OF THE WORKING CONDITIONS OF THE RECYCLING OF ALUMINIUM ALLOYS

TSMU, Department of Environmental Health and Professional Medicine, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-38-41.

Some characteristics of working conditions of secondarey processing (recycling) of aluminum alloys are studied.

The study founded that the peculiarities of the technology of secondary processing of aluminum cause the generation of hot industrial microclimate, moderately elevated dust concentartions of work zone air and significant industrial noise parameters.

11.1N.D.KOBESHAVIDZE, 2D.P.CHIKVILADZE, 2KH.E.GACHECHILADZE, 2M.L.MIKELADZE

THE DYNAMICS OF MICROBIAL COLONIZATION OF THE URINARY TRACT IN PRETERM INFANTS

1LTD “Imedis Klinika” Tbilisi, 2Tbilisi State Medical University, Department of Microbiology,

Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-41-44.

The article presents the data on study of dynamics of microbial colonization of the urinary tract in 124 premature infants in the Department of Critical Medicine at the LTD “Imedis Clinic” Tbilisi. Qualitative and quantitative microbiological analysis of urine was carried out, using modern research methods. In the first 72 hours after birth, as well as on the 14th and 30th day of birth. In the first 72 hours from the moment of birth, in no single urine samples were isolated microorganisms, whereas on the 14th day of birth, positive bacteriuria was detected in 14 (11.29%) cases, and microbial strains, mainly coagulase negative staphylococci (92, 86%) 102-104 CFU (Colony Forming Unit). On the 30th day from the moment of birth, the picture changed and the microbial structure was presented mainly by representatives of gram-negative micro flora in (87.5%). Determination of microorganisms’ sensitivity/resistance to antibiotics of different groups, was detected by disk diffusion and serial dilution tests on solid nutrient medium.

Thus, during the entire neonatal period, microbiologically confirmed bacteriuria was established.

12. 1N.D.KOBESHAVIDZE, 2D.P.CHIKVILADZE, 2KH.E.GACHECHILADZE, 2M.L.MIKELADZE

DYNAMICS OF MICROBIAL COLONIZATION OF THE INTESTINAL TRACT IN PRETERM INFANTS

1LTD “Imedis Klinika”, 2Tbilisi State Medical University, Department of Microbiology, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-44-51.

The article presents the process of microbial colonization of the intestinal tract of 124 premature newborns being treated at the “Imedis Clinic” in Tbilisi. Premature infants with nearly the same gestational age and body weight were divided into two groups. In the main group there were 59 (47.58%) premature infants who received probiotics along with the basic therapies, and 65 (52.42%) in the control group who received only the basic therapy. Qualitative and quantitative microbiological analysis of feces, using modern research methods, was carried out in the first 72 hours from the moment of birth, as well as on the 14th and 30th days. In the first 72 hours after birth, no microorganism was isolated in any sample of feces in both groups. Studies on the 14th day from the moment of birth of newborns showed that in both groups almost all newborns had pronounced disorders of microbial colonization of mucous membranes of large intestine, with mainly hemolytic staphylococci and Enterococci, which dominated on gram-negative enteric bacteria, thus, no anaerobes were detected in stool samples. On the 30th day, significant differences in groups were identified in the microbial structure of the feces, so in the main group of infants, bifidobacterium and lactobacilli were isolated in 49 (83.05%) cases, and only in 25 (38.46%) cases in the control group. In the main group were children who had received basic therapy and probiotics, the growth range of bifidobacterium and lactobacilli was in 105- 107 CFU / g. Study of the incidence and severity of necrotizing enterocolitis showed that the severe course of the disease in the main group was detected in 32.20% of cases, whereas in the control group - 44.62%. Significant differences in the severity of necrotizing enterocolitis were identified. In premature infants with an extremely critical body weight, from the control group, severe enterocolitis was observed more often.

13. JAVAKHADZE R., GVINERIA I., KHATIASHVILI N., ONIANI T., GHVABERIDZE O., SVANIDZE T.

ASBESTOS-INDUCED TRENDS IN EUROPE AND GEORGIA

N. Makhviladze Research/Scientific Institute of Labor Medicine and Ecology, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-51-54.

The problem of asbestos influence on the health of people is the subject of discussion in the whole world. Many countries resolved the “asbestos problem” by banning the use of asbestos, and some only by a partial restriction. The article provides an overview of the literature on the detection, consumption of asbestos and its harmful effects on human health worldwide and in Georgia, as well as data from practical and scientific publications on various diseases (asbestosis, lung carcinoma, mesothelioma) associated with asbestos.

From the proposed review, it follows that chrysotile, included in the list of carcinogens of the 1st group, is still the subject of research by specialists; there are no differences in the degree of danger between the types of asbestos and there is no of its permissible level in the air; a disappointing forecast is made about the number of diseases and the growth of mortality in the future.

14. R.JAVAKHADZE, M.KVATADZE, M.ARABIDZE, AL.CHIKOVANI,

KH.SHUBLADZE, KH.CHIGOGIDZE

AN OCCUPATIONAL HAZARD AMONG WORKERS OF WAGON-REPAIR INDUSTRY

N. Makhviladze Research/Scientific Institute of Labor Medicine and Ecology, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-54-57.

The article presents the results of hygienic and clinical studies conducted in the wagon-repair industry. It has been established that the leading factor in the production environment is noise (class of working conditions 3.1., 3.2., 3.3.), microclimate (class 3.1-3.2), severity of the labor process (class 3.1-3.2), dust and harmful chemicals (class 3.1-3.2) . Clinical studies have shown that the leading ones are diseases of the cardiovascular and the musculoskeletal systems, which can be considered occupationally caused diseases for this production.

15. H.PHAGAVA, I.MCHEDLISHVILI

DEVELOPMENT OF CURRICULUM FOR ELECTIVE COURSE “SYSTEMATIC REVIEW AND META-ANALYSIS”

Department of Epidemiology and Biostatistics, Tbilisi State Medical University

J. Experimental and Clinical Medicine, 2019, 3, pp-57-59.

Introduction. Systematic review permits to summarize the findings of various studies. Meta-analysis permits to combine findings from different independent studies and provide a precise estimate of the clinical effect or diagnostic power. Aim. To develop curriculum for the elective course on systematic review and meta-analysis at the Tbilisi State Medical University. Materials and Methods. The literature review was done. There were also used the materials received during the Summer School in Epidemiology and fellowship funded by DAAD (German Academic Exchange Service) to Ulm University, Germany. The opinion of the experts regarding curriculum development was taken into account. Results. The course will be run at the Department of Epidemiology and Biostatistics during 8 days with one day at the computer lab in the library. The course will be equal to 2 ECTS with 26 contact hours. Course admission requirement is some knowledge of English language. Students will be assessed according to the corresponding regulatory rules of Georgia and administrative-legislative acts of the Tbilisi State Medical University with 100-score system. The course will cover fundamentals of systematic review and meta-analysis. Conclusion. Basic knowledge of systematic review and meta-analysis is very important for practical physician, healthcare worker, scientist and academic staff. For successful implementation of the elective course its piloting is advisable.

16. K. MURJIKNELI, T. DARSANIA, N. GARUCHAVA, L. BAKRADZE, MAIA TSIMAKURIDZE

THE USE OF TISSUE-EQUIVALENT THERMOLUMINESCENT DETECTORS FOR THE STUDY OF DOSES IN MUSCLE AND BONE TISSUE DURING RADIOTHERAPY

TSMU, Environmental health and occupational medicine department, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-59-62.

Thermoluminescent detectors, equivalent to a given tissue, are promising for solving problems of biomedical dosimetry. The modes of radiation generation in close-focus radiotherapy should be differentiated depending on the depth of germination of the tumor. The mode usually used in practice (voltage 40-50 kV, filter 2.5 mm Al) is suitable only for tumors having a thickness of 5-10 mm.

17. 1TOPCHIYEVA SH.A., 2GORGASLIDZE N., 3KERIMOVA R.Z., 4YILDIZ L.Z.,

ALLAHVERDIYEVA R.Z.

ELECTROPHYSICAL PROPERTIES OF VENOM OF A HONEY BEE - APIS MELLIFERA L. CAUCASICA

1Institute of Zoology of NAS of Azerbaijan, Baku; 2Tbilisi State Medical University, I.Kutateladze Institute of Pharmacochemistry; 3Azerbaijan State Medical University, Baku; 4Recep Tayyip Erdoðan University (RTEU), Medical Faculty, Department of Medical Physiology, Turkey

J. Experimental and Clinical Medicine, 2019, 3, pp-62-65.

In the work presented, We investigated specific resistance of venom of a honey bee Apis mellifera L. Caucasica. In order to measure specific resistance of the crystals depending on heating temperature, the investigated crystal was pasted on a metal substrate by silver paste, and the second electrode was pasted on other surface with the same paste. Thus, (“sandwich”) structure was created for thefurther investigation of electrophysical parameters of bee venom. Heating of bee venom sample with constant velocity of 2K/min. was conducted in a measuring cell. Measurement of resistance was carried out by teraohmmeter Е6-13А.

The sample was heated and change of its specific resistance was observed, then it was cooled and the experiment was repeated for several times. The maximum value of specific resistance was obtained at the temperature of 1250C. The experiment was repeated a day later. Displacement of maxima occurred on specific resistance-temperature curve. We assume that after each heating structural changes (fracture of bonds) and in its turn change of pharmacological activity of enzymes occur in the sample. However, after heating of bee venom in the range of 24 hours the fractured bonds are restored, restoration of enzymes’ activity and physical and chemical properties of venom is noticed that justifies thermo stability of honey bee venom. Thus, electrophysical properties of snake venom were experimentally revealed. It was established that at heating up to the temperature of 1250C, crystals of venom of a honey bee Apis mellifera L. Caucasica have maximum resistance, and after cooling its property restore. The obtained data can be applied at storage of preparations on the basis of bee venom.

18. 1TOPCHIYEVA SH.A., 2GORGASLIDZE N, 3MEHRABOVA M.A., 4KARIMOVA R.Z.,

5YILDIZ L.Z

ENVIRONMENTAL MONITORING OF ATMOSPHERIC AIR POLLUTION WITH RADIONUCLIDES USING MOSS BIOINDICATORS

1Institute of Zoology of NAS of Azerbaijan; 2 Tbilisi Medical University, I.Kutateladze Institute of Pharmacochemistry, Georgia; 3Institute of Radiation Problems of NAS of Azerbaijan, Baku; 4 Azerbaijan Medical University, Baku; 5Recep Tayyip Erdoðan University (RTEU), Medical Faculty, Department of Medical Physiology, Turkey

J. Experimental and Clinical Medicine, 2019, 3, pp-65-69.

The purpose of our research was to identify the degree of air pollution with radionuclides using moss bioindicators.

We studied samples of moss and soil (near Mingechaur, Baku) to identify the bio-indicator properties of moss and for bioindication of air and soil.

We studied samples of moss, soil and water near Mingechaur city and Baku city regions .

The activity of radionuclides were determined on Gamma spectrometer. Determination of content and activity of the radionuclides in the tests of soil, plant and water, was carried out at “Canberra” (USA)ã-spectrometer with high a purity germanium detector (HP Ge).

It was determined the activity of radionuclides (7Be, 40K, 60Co, 208Tl, 134Cs, 137Cs, 210Bi, 212Bi, 212Pb) in the samples of of moss, soil and water samples taken from the Mingechaur region and in Baku region of the Azerbaijan Republic.

As a result of the research it was revealedå the activity of 40K was more than other isotopes (648,1 Bq/kg). It was found out 7Be of activity 79.08 Bq/kg, 214Pb of activity 62.62Bq/kg, 214Bi of activity 28.74 Bq/kg, 137Cs of activity 14.01 Bq/kg, 134Cs of activity 12.15 Bq/kg, 60Co of activity 11.34 Bq/kg and oters, which were more in Mingechaur region than in Baku.

19. 1TOPCHIYEVA SH.A., 2GORGASLIDZE N., 3SALAHOVA S.Z., 4YILDIZ L.Z.,

5KERIMOVA R.Z., ALLAHVERDIYEVA R.Z.

MOSSES - BIOINDICATORS IN THE ENVIRONMENTAL MONITORING OF AIR POLLUTION BY METAL IONS AND RADIONUCLIDES

1Institute of Zoology of NAS of Azerbaijan, Baku; 2Tbilisi Medical University, I.Kutateladze Institute of Pharmacochemistry, Georgia; 3SOCAR, Ecology department, Complex Research Laboratory; 4Recep Tayyip Erdoðan University (RTEU), Medical Faculty, Department of Medical Physiology, Turkey; 5Azerbaijan State Medical University, Baku.

J. Experimental and Clinical Medicine, 2019, 3, pp-69-73.

The purpose of our research was to identify the degree of air pollution with ions of mettals and radionuclides using moss bioindicators. For the studied samples of moss and soil near Mingechaur, Baku to identify the bioindicator properties of moss and for bioindication of air and soil. Concentrations of heavy metals were determined on an Agilent Technologies 7500 Series ICP-MS (7500cx) instrument using inductively coupled plasma mass spectrometry (ICP-MS, USA).

The activity of radionuclides were determined on Gamma spectrometer “Canberra” (USA)γ-spectrometer with high a purity germanium detector (HP Ge). The content of heavy metals in the studied samples collected from the most polluted area nearthe city of Sumgait was experimentally determined, and for samples of mosses, they were Cd (0.61976), (Cu (64.28251), Ni (22.75801), Pb (65.70956), Zn (167.50293) and Hg (0.091319); for soil samples, Cd (0.29681), (Cu (27.61957), Ni (25.669), Pb (28.596), Zn (87.10275) and Hg (0.090798) mg / kg, respectively.

20. 1AHMADOV E.I., HASANOVA J.V., MAMMADOVA F.Z., TOPCHIYEVA SH.À., 2GORGASLIDZE N.

EFFECTS OF THE ARTEMISIA ABSINTHIUM L. EXTRACTS ON EIMERIA TENELLA OOCYSTS IN VITRO

1Institute of Zoology of the Azerbaijan National Academy of Sciences, Baku; 2Tbilisi Medical University, I.Kutateladze Institute of Pharmacochemistry; Department of Social & Clinical Pharmacy, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-73-77.

This study investigated the effects of wormwood extract (A.absinthium) on E.tenella oocysts in vitro. E.tenella oocysts from feces of infected chickens were isolated by flotation and divided into two groups. One part of the oocysts remained unsporulated, the other were stored in a 2.5% of potassium dichromate solution at 27°C for sporulation. The effect of 25, 50 and 100 mg/ml doses of A.absinthium extract on both groups of oocysts was studied for 72 hours. Baycox with 1 mg/ml dose and of potassium dichromate solution (2.5%) were used for a control. The study revealed that, regardless of the dose, A.absinthium extract has an anticoccidial efficacy of on sporulated and unsporulated oocysts of E.tenella. 100 mg/ml dose of the extract of A.absinthium of prevents the sporulation of 95% oocysts, and also does not preserve viability of 94% of sporulated oocysts. The same situation is when using 1 mg/ml a dose of Baycox at during incubation of oocysts at 27° C for 72 hours. This dose of Baycox prevents the sporulation of oocysts and leads to the deformation and lysis of 96% of the sporulated oocysts. The anticoccidial efficacy of a 2.5% potassium dichromate solution for unsporulated oocysts was 3%. The results of the research revealed an anticocidial effect of the extract of bitter wormwood.

21. MEBONIA N.1,2, ZHIZHILASHVILI S.1, ZHIZHILASHVILI A.1, VEKUA N.1, GABRICHIDZE T.1, GURAMISHVILI S.1, KIKNADZE K.1, PARULAVA M.1

MAIN CHARACTERISTICS OF THYROID CANCER GLOBAL DISTRIBUTION

1Tbilisi State Medical University; 2National Center for Disease Control and Public Health;

Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-77-79.

Introduction. Over the past few decades, in many countries of the world there has been a steady increase in the incidence of thyroid cancer (TC), and this growth mainly affects the female population. Recent evidence suggests that thyroid cancer is the fifth most common malignant neoplasm in women. The goal of this study was to assess the global and regional prevalence of thyroid cancer.

Methods. An overview of the results of scientific studies on epidemiologic characteristics of thyroid cancer published in the PubMed database from 2000-2018 was performed.

Results. Rate of increasing morbidity of thyroid cancer vary by country: in most countries, the incidence has doubled, but in selected countries more than tripled since the 1980; mortality has been declined in both sexes. At global level male/female ratio equals to 1:1.3. The increase in the incidence of thyroid cancer is mainly due to an increase in the papillary histotype that have a good prognosis.

Conclusions. Increase of the incidence of thyroid cancer most likely due to two related factors: increased detection and real increase of new cases, caused by unknown thyroid-specific environmental carcinogens. Existing situation needs farther epidemiological investigation in order to identify new risk-factors.

22. M.NIKOLAISHVILI, T.MUSELIANI, KH.DONDOLADZE

ECOTOURISM IN KAKHETI ON THE EXAMPLE OF THE RIVER ALAZANI

Iv.Beritashvili Center of Experimental Biomedicine Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-79-81.

River. ALAZANI coastline and the surrounding areas of water microbiological analysis showed that, we have studied regions, microbiological Contamination can safely be epidemiologically at the cost of cleaning up.In Europe, located in the Caucasus primitive nature the greatest impact on the health of the population in industrialized health. Both directly for its recreational potential, as well as indirectly - endemism, which is the most important is the development of tourism.

23. 1B.KORSANTIA, 2,4G.PICHKHAIA, 2TS.SUMBADZE, 2S.MARKARIAN, 2S.GVIDANI,

3M.GOGOTISHVILI

TEST OF THE COMBINED MODULE FOR WATER DISINFECTION DURING EXPERIMENTAL STAPHYLOCOCCUS INFECTION

TSMU V.Bakhutashvili Institute of Medical Biotechnology; TSU A.Natishvili Institute of Morphology. Tbilisi, 3Shota Rustaveli State University, Batumi; 4Caucasus International University, Tbilisi, Georgia

J. Experimental and Clinical Medicine, 2019, 3, pp-81-86.

The purpose of this study was to test the combined module for water disinfection for the presence of an antimicrobial (Staphylococcus aureus) activity in a specific liquid environment. A portable module for drinking and wastewater disinfection (patented in Georgia, GE P 2013 5987B), was taken as an analog.

For the first time on the actual material (generator + infected saline) we revealed a reliable bactericidal effect on staphylococci. The intensity of the neutralization of staphylococci mainly depended on the exposure time of the generator, as well as on the initial dose of microbes, i.e., the degree of water pollution.

The bactericidal effect of the module was confirmed not only in saline but also in distilled water and household tap water. We emphasize that in this experiment the non-sterile liquid was used for the first time. It also turned out that a 60-second exposure provided reliable antimicrobial protection of the liquids used within the first 6 days of the experiment.