J.EXPERIMENTAL & CLINICAL MEDICINE
2015, ¹ 4
1. N. VEPKHVADZE, M. GIORGOBIANI, B. ZURASHVILI, N. KILADZE,
O. MAMATSASHVILI
ECOCATASTROPHES RISK REDUCTION WAYS
Tbilisi State Medical University, Faculty of public health, Department of preventive medicine and environmental health. Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.10-12
Natural disasters, risk threats arising from hydro meteorological, geological and other aspects as well modern approaches to risk reduction measures have been discussed.
Highlighted that to save population, infrastructure and national values, each country should implement effective measures aimed to sustainable development and disaster risk reduction, raising knowledge, capacity building and strengthening the motivation.
2. S.BEZARASHVILI, R.KVERENCHKHILADZE, M.ARABIDZE, G.KVERENCHKHILADZE
HYGIENIC RATE OF ATMOSPHERE DUSTINESS CONDITION OF TBILISI
TSMU, Department of Environmental Health and Occupational Medicine. National Environmental Agency of the Ministry of Environment and Natural Resources Protection of Georgia, Tbilis
J. Experimental and Clinical Medicine, 2015, 4, pp.12-15
The data obtained as a result of monitoring the Tbilisi City atmosphere dustiness by the National Environmental Agency of the Ministry of Environment and Natural Resources Protection of Georgia are analyzed. Also are analyzed the 2005-2014 data on Tbilisi air pollution. The average annual, average monthly, maximum one-time dust concentrations and average monthly dust concentartions according to individual months in the ambient air of Tbilisi City are studied. The unfavorable state of pollution of Tbilisi City atomospheric air with solid particulates (dust) is established. The main air pollutant are the exhaust gases of motor transport. The central ditsricts of Tbilisi are especially subjected to the pollution with particulate pollutants. This circumstance is very important in terms of a possible adverse impact of the ambient air on the state of health of the urban population.
3. I.MCHEDLISHVILI, N.MAMUCHISHVILI, T.MCHEDLISHVILI, D.GELOVANI
PREVALENCE OF CRIMEAN-CONGO FEVER IN GEORGIA
Tbilisi State Medical University, Public Health Department; Center of Disease Control and Public Health, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.15-17
Index cases of Crimean-Congo Fever in Georgia was reported in 2009. During 2013-2014 the infection acquired an epidemic pattern. 13 cases were detected in 2013 and 24 cases – in 2014. Primarily all the cases were reported in the Eastern Georgia. The most intensive spread was observed in Khashuri region, which accounted for 56.7% of the reported cases. In 2014 the disease began to spread in the Western Georgia, namely in Bagdadi region.
4. B. KURASHVILI, S. ZARNADZE, L. BAKRADZE, T. DARSANIA
ASSESSMENT OF FOOD SANITARY-BACTERIOLOGIC TESTING RESULTS IN GEORGIA 2013-2014
TSMU, Nutritional and Age Medicine Department, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.17-20
Analyzed results of sanitary-bacteriological laboratory examination of food and water samples, carried out in Georgia in 2013-2014 by the National Food Agency of Ministry of Agriculture, detected misbalances of microbiological parameters in 73% (202 food and water samples out of 822, tested in 2013, didn’t satisfy norms), physicochemical type disorders were detected in 14% and other quality type violations. In 2014 were examined 930 samples of food and water (pathogenic microorganisms - Salmonella and Listeria Monocytogenes were detected in 0.8%) and so, 91.1% -microbiological disorders, physicochemical in 4.4%, quality type – 2.8% and incorrect labeling in 1.7%. Inspection of food and water safety increased twice in 2014 than in 2013, therefore, detection of pathogenic and conditionally pathogenic microorganisms in culinary products increased, as a result of deficiencies of sanitary norms and conditions. We recommend, prompt sanitary-hygiene surveillance, monitoring of food and water safety, controlling transportation, cooking, realization and storing of products.
5. L. GIORGOBIANI, E. MIRVELASHVILI, B. ZURASHVILI, E. TSETSADZE
TOBACCO POLICY AND HEALTH PROMOTION IN TBILISI UNIVERSITIES
International health school of TSMU, The direction of health promotion, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.20-22
The purpose of the issue was to present how the tobacco policy is in Tbilisi universities and what activities are taken to create a smoke-free learning space. For that purpose, the research was conducted in three state and two private universities.
Resent research has indicated that it is necessary to conduct serious educational works to eliminate smoking in students and establish a healthy lifestyle. Furthermore, it is required to refine the existing legal framework for the health promotion.
6. M. NIKOLAISHVILI, S. BERIASHVILI, K. FRANCHUK, T. TUPINASHVILI
ENDOCRINE PATHOLOGIES OF THYROID GLAND IN CLINICAL AND FUNCTIONAL CONDITIONS OF THE ORAL CAVITY
D. Aghmashenebeli State University, Dental Clinic; Iv. Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.22-27
No new strips were identified in the spectrum of oral fluid in adolescents with thyroid dysfunction, but there were found significant quantitative and qualitative changes in mineralization of oral cavity fluid. Both types of cariogenic bacteria play an important role in the pathogenesis of the disease, but Str. Mutans attracts more attention than the Lactobacilli and other microorganisms that are less significant for the acid formation, because it is Str. Mutans that initiates the enamel demineralization.
Also saliva microcrystallization of type III prevails in adolescents with thyroid dysfunction and high level caries intensity, while the control groups have a low intensity level of caries – with saliva microcrystallization of type I.
7. A. KOCHLAMAZASHVILI, M. NASKIDASHVILI
ROLE OF DIOSCORID MONOTHERAPY IN OLD AGED PATIENTS
WITH ANGINAL PAIN
Medical Center “Extra”, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.27-29
After monotherapy treatment conducted with Dioscorid (daily dose amounted 900mg): to 15 patients with anginal pain 8 (53%) of them relived, 6 (60%) patients out of 10 stabilized; from 11 cases of Extrasystole arrythmia 8(73%) patients have been taken under surveillance, and from 12 patients With chronic fatigue syndrome 11 of them were lifted. none of this cases drug dioscoride have not revealed any side effects or individual disagreement.
Based on this researches, which envisioned study of new antioxidant drug dioscorid’s role in monotherapy, in ages between 75 to 85, the following conclusions:
1. Combined, herbal antioxidant drug Dioscorid is safely, noncuring model, which can be used within aging patients with heart’s ischemic disease.
2. Within aging patients Dioscorid relieves: 53% of anginal pain, 60% Transient hypertension and 73% extrasystole arrhythmia.
3. Dioscorid in 92% of the cases removes chronic fatigue syndrome, which is Accompanying aging patients with heart’s ischemic disease.
8. K.GAMBASHIDZE, T.PETRIASHVILI, N.PKHALADZE, N.BEZHITASHVILI, T.PKHALADZE, T. SANIKIDZE
REDOX-STATUS AND EFFICACY OF ANTIOXIDANT THERAPY IN MICE WITH EHRLICH CARCINOMA
Tbilisi State Medical University, Department of Pathophysiology, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.29-32
In the presented article the redox-status and electron paramagnetic centers (Fe2+, Mn2+, NO, Fe3+-transferrin, FeS, FeS-NO, Met-Hb, cytochrome P-450, oxidized ceruloplasmin) of the blood and liver in mice with Ehrlich carcinoma has been studied before and after treatment with a-tocopherol using electron-paramagnetic resonance (EPR) method. Investigations have shown paraneoplastic alterations of redox-status in mice with cancer. EPR specter of the blood and liver tissue revealed disorders of mitochondrial respiration, decreased activity of antioxidant system, exaggerated lipid peroxidation (POL) and altered processes of detoxication.
a-tocopherol injections vividly improved the above-mentioned paraneoplastic disturbances of redox-status.
Experiment have shown that á-tocopherol, improves electron transport at NAD.H-ubiquinon-oxidreductase locus and mitochondrial respiration, increases antioxidant system activity, decreases process of POL supporting stabilization of membrane structures with further decrease in processes of cellular destruction. Administration of antioxidants using optimally selected regimen of treatment has been suggested.
9. E. TANDILASHVILI, V. MARGVELASHVILI, I. ZARNADZE
POSSIBLE RELATIONSHIP BETWEEN ENAMEL DEFECTS AND SYSTEMIC DISEASES
Iv. Javakhishvili Tbilisi State University; Tbilisi State Medical University; Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.32-35
The epidemiology of enamel defects has a rich history. Non-carious lesions, like erosion, fluorosis, hypoplasia, abfraction and abrasion have been described early in XIX century. Although,non-carious lesions are less studied, than dental caries, many scientists argue their union to systemic diseases. Pubmed Central, Medline, Embase were searched to review scientific literature in this filed. According to this data, we can conclude, that systemic diseases has strong relationship in development of enamel defects.
10. N.NEMSITSVERIDZE, T.CHUMBURIDZE, N.GORGASLIDZE,
N.APTSIAURI, I.TSURTSUMIA, M.BLUASHVILI
IMPORTANCE OF BIOEQUIVALENCE AT PHARMACEUTICAL CARE
TSMU Department of Social and Clinical Pharmacy, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.35-37
The quality of medical preparations/ pharmaceuticals is considered as an important problem in modern pharmacy. Increasing the percentage of generic products on the Georgian pharmaceutical market (90-95%) raises the doubts about generics whether they correspond to their originals or not. Is it possible to replace the original not to harm the patient? Doctors and pharmacists should pay particular attention to the indices of bioequivalence and bioavailability of medicines.
The aim of this study was to determine the awareness amongst doctors and pharmacists about the bioequivalence of medicines. A survey of physicians and pharmacists was carried out in Tbilisi and Akhaltsikhe (50 respondents). It was found that, unfortunately, neither the doctors nor pharmacists are insufficiently aware and not attach particular importance to the issues of bioequivalence, moreover, there is no directory with the data on the bioequivalence of pharmaceuticals in Georgian pharmaceutical market. The low level of awareness amongst pharmacists on the subject can be solved by trainings to introduce innovations and recommendations of WHO and FIP and increase qualification of pharmacists.
11. 1N.N. AVAZASHVILI, 2 I.M. MCHEDLISHVILI, 3T.I. NOZADZE, 4D.P. CHIKVILADZE,
4KH.E. GACHECHILADZE, 4M.L. MIKELADZE
MICROBIOLOGICAL EXAMINATION OF MEDICAL WASTE IN TRAUMATOLOGICAL DEPARTMENT
1Ltd “Centre of Urgent Surgery and Traumatology”, Tbilisi; 2Tbilisi State Medical University, Department of Public Health; 3Department of Clinical science, Direction of Traumatology and Orthopedics; 4Department of Pathology and Forensic Medicine, Direction of Microbiology;
Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.37-42
In this article, there are given date of microbiological examination of medical waste samples, taken in traumatological departments. Examination was carried out during 2015 year. Microorganisms, which in some cases were isolated from disinfected medical waste, have shown polyresistancy to antibiotics, stability to disinfectants and were virulent in comparison to microorganisms, which were isolated before disinfection. All this indicates on their possibly nosocomial origin. Thereby, permanent microbiological examination of disinfected medical waste samples, may be regarded as one of the methods of detection of hospital strains.
12. 1D.D.KOBESHAVIDZE, 2D.P.CHIKVILADZE, 2KH.E.GACHECHILADZE, 2M.L.MIKELADZE
COMPARATIVE ANALYSIS OF MICROBIAL STRUCTURES OF NEWBORNES AND PUERPERAL, DEPENDING ON THEIR JOINT OR SEPARATE STAY MATERNITY DEPARTMENT
1Ltd “Imedis Clinic”, Tbilisi: 2Tbilisi State Medical University, department of pathology and forensic medicine, direction of microbiology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.42-46
In this article, there are given results of microbiological study, held on newborns and puerperas. Study was performed with taking into account of their joint or separate type of stay in postnatal ward of maternity department. The aim of study was to reveal level of their microbial contamination. Investigation was performed among 30 pairs of newborns and puerperas, which were staying together in postnatal ward, and 18 pairs of them who were staying separately. It was determined, that while joint stay of newborns and puerperas, microbial structures isolated from them were almost identical, and quantity of gram-positive microorganisms exceeded several times on number of isolated gram-negative microorganisms. While separate stay of newborns and puerperas, multiplicity of microbial structures was found out. Several microbial species were isolated in big numbers (CFU – was 103-105) and prevalence of gram-positive microflora was seen.
Received data confirm, that joint stay of newborns and puerperas creates close contact between them, insulates them from other patients and clinical stuff, and also creates preconditions for significant decrease of frequency of purulent inflammatory infections development.
13. T. LAGIDZE, T. SHAMATAVA, Z. GIORGAIA
THE STUDY OF CERTAIN ASPECTS OF THE PRODUCTION BIOFUEL AND DEVELOPMENT OF BIOENERGY IN GEORGIA
St. Andrew the First-Called Georgian University of the Patriarchate of Georgia, Tbilisi
J. Experimental and Clinical Medicine, 2015, 4, pp.46-48
The article analyzes the current state of Georgia according to its fuel-energy resources and the rate of biomass usage for bio-fuel production. In the light of the newest achievements in the field of biotechnology, methods and means of conversion of biomass into other forms of energy enhances the need for extensive use of biomass for production of alternative types fuel.
14. N. GORGASLIDZE, Z. ANTELIDZE, M. GETIA
SCIENTIFIC RESEARCH ACTIVITIES AND ENVIRONMENT
TSMU Department of Social and Clinical Pharmacy;
TSMU I.Kutateladze Institute of Pharmacochemistry, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.48-52
Effective maintenance of aggressive substances does not mean only guarding of environment, but also reducing the expenditures. Efficient use of resources gives possibility to reduce unnecessary costs that is the aim of the organization.
When operating, the researcher is due to eliminate or minimize the risks in order to prevent harmful effects on both environment and humans.
The research plan model, that was elaborated at the I.Kutateladze Institute of Pharmacochemistry aims to leverage research activity, as well as its efficacy and safety.
15. T. SHISHNIASHVILI, N. SULADZE, S. LITANISHVILI
THE DEFINITION OF ESSENTIAL ELEMENTS IN TOOTH ENAMEL AND DENTIN
TO ASSESS THEIR EFFECTS ON THE CHILDREN
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.52-54
Spectral analysis of dental hard tissues revealed the reduced number of essential elements in little children’s carious teeth. Our study showed not only the impact of essential elements content on teeth mineralization, but also gave us an ability to monitor the deficiency of these elements in human organism.
16. KH. DONDOLADZE, D. ZURABASHVILI, M. NIKOLAISHVILI, S. ZENAISHVILI
ELECTROMAGNETIC FIELD, AS A STRESS FACTOR OFFICES WORKING FEMALE‘S PSYCHO-EMOTIONAL STATE
Center for Mental Health and Prevention of Addiction, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.54-60
The electromagnetic field affects the human mental condition. Individuals who spend more than 56 hours a week under the electromagnetic field, are more vulnerable to mental health disorders compared to those who have less time in the presence of EMF. Frequent headaches, dizziness, giddiness, attention and concentration impairment, anxiety, increased aggression, excessive weight, endocrine and metabolic disorders frequency and severity is different for persons who are in EMF constantly, often and rarely.
17. T. SHISHNIASHVILI, T. SULADZE, M. MAKHVILADZE, E. LITANISHVILI
EFFECTS OF IMBALANCE OF MICROFLORA OF THE GASTROINTESTINAL TRACT AT THE ORAL DISEASE IN CHILDREN
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.60-62
Dental and general health status in children and adolescents is highly dependent on severity of GI tract pathologies, particularly on qualitative and/or quantitative content of microbyotes of tract.
18. L. MURUSIDZE, I. ZARNADZE, SH. ZARNADZE
THE ASSESSMENT OF DOCTORS HR PARTICIPATION IN DEVELOPMENT OF RESORT AND MEDICAL TOURISM
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.62-65
Our country has got rather climate-balneological resource to become the advanced country of health and treatment tourism in Caucasus region. Because of natural factors and variety (fresh air, mineral waters and healing mud) in Georgia there are identified nearly 340 health-treatment zones which are used for health care and to prevent some harmful diseases.
19. L. BENASHVILI, I. KAKHNIASHVILI, D. TOPURIA, M. MATOSHVILI, T. TURMANIDZE
INFLUENCE OF IRINOTECAN ON LIVER REGENERATION
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.65-69
The aim of this study was to determine the effect of Irinotecan, one of the most frequently used agent in the treatment of metastatic colorectal cancer [CRC] on liver regeneration and show its correlation with steatosis and steatohepatitis in a rat model. The experimental study showed that Irinotecan did not affect the liver regeneration adversely. In order to show the effects of Irinotecan on liver regeneration in humans further clinical studies are needed.
20. MINDADZE T., KOMAKHIDZE N., ABAISHVILI N.
CORRELATION BETWEEN ANOMALIES OF DENTAL SYSTEM AND
SINDROM OF NAZAL OBSTRUCTION
David Aghmashenebeli University of Georgia, Tbilisi
J. Experimental and Clinical Medicine, 2015, 4, pp.69-72
The aim of this research is to study correlations between anomalies of dental system and nazal obstruction. We investigated 134 patients. 70 patients are in the first group and have adenoids and 64 patients are in the second group and have no adenoids present. Corelation analysis showed, that 74% of patients from the first group have anomalies of dental system, and from the 2nd group have such anomalies only 33%.
Therefore, it is very important to find correlations between anomalies of dental system and nazal obstructions, so that certain algorithms can be established and orthodontists and otorynolaringologists can solve this complex problem.
21. VASHADZE SH., ARTMELADZE M.
PANIC ATTACKS AND CANCER
Rustaveli State University, MedCenter, Batumi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.72-75
According to statistics number of patients suffering from cancer rise every year. Study was conducted in oncological center of Adjara. Shixan’ scale was used during research. Research involved 200 patient aged from 20 year to 75, from them 130 were female and 70 male. 45 of them had surgery for treatment of cancer, 16 – had chemotherapy treatment, radiotherapy – 14 and combined therapy – 125, patients with lung cancer – 6, breast cancer – 22, skin cancer – 16, gastric cancer – 27, bladder cancer – 24, ovarian cancer – 35 , uterus cancer – 25, larynx cancer – 15, prostate cancer – 30.
Symptoms were evaluated with use of Shixan scale and according to results: agitation levels higher then 30 points was normal and higher than 80 points was high. During panic disorder this level is in the range of 57 points. According to research panic attack happened 15-20 times in month in 55 female patients and 35 male patients. Rare (5-10 panic attack in month) in 25 female patient and 45 male patient. Feeling of unsuccessfulness was found in 75 female and 45 male patients. Social disorders were found in 75 female and 22 male patients. Change in level of willingness in 80 female and 35 male patients.
According to this data, one of the treatment priority of oncological patients is psychological support after diagnosis till the end of treatment. Psychological awareness of patient and his/her family members is significant factor of treatment. Cost free psychological rehabilitation centers on the base of oncoclinics should be established. Psychological rehabilitation and management of psychiatric disorders should be significant part of treatment process of patient with cancer.
22. STURUA M., SAMSONIA SH., TSAQADZE D., GORELASHVILI N.
RELEASE OF BIOLOGICALLY ACTIVE AGENTS FROM PLANTS: MAGNOLIA OBOVATA, MAGNOLIA GRANDIFLORA AND STUDY OF THEIR EFFECT ON THE ORGANISM IN EXPERIMENTS
Iv.Javakhishvili Tbilisi State University; Tbilisi Medical Teaching University “Hippocrates“, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.75-79
Two types of the plant Magnolia: Deciduous Magnolia obovata, Evergreen Magnolia grandiflora were researched by me on the content of biologically active organic compounds. Total parameters were received from the indicated plants, from which, using modern methods of chromatography, were received phenolic compounds, Alkaloids and essential oils. On the basis of spectral analysis, separate alkaloids were identified.
The following alkaloids were released from both types of the above indicated Magnolia: Anonain, Remerin, Liriodenin, Lanuginose, Isolaureline N-oxide, Remerin N-oxide and dehydroremerin.
Big quantitis of phenolic compounds were found in the composition of Magnolia obovatas leaves, for instance Isopheric acid, and the essential oils in the composition of Magnolia grandiflora.
Release of biologically active agents, alkaloids, phenolic compounds and identification using modern methods of chromatography of analysis.
During the study of biological activity of water and alcohol extracts of Magnolia obovata it appeared that they reveal selective-biocidal action toward test-microorganisms and that is why it can be used against aktinomitsita and phytopathogenic microorganisms Bacilus substilis, Xanthomonas campestris, streptomyces albogriseolus subsp. Aragviensis.
In the composition of the leaves and flowers of both types of Magnolia obovata and Magnolia grandiflora the percentage content of alkaloids and phenolic compounds is being increased with the increase in age of these plants. General contents of both types of Magnolia are Remerin and Liriodenin, it was appeared in leaves of these plants in all periods of vegetation: it is also known that both these alkaloids are characterized by tumor inhibiting characters. This circumstance makes our research more important.
23. ANDGULADZE L., JOKHADZE M., MOSHIASHVILI G., MAKHARADZE R., IMNADZE N., KITEISHVILI D., BUKHNIKASHVILI K., CHAVCHANIDZE T.
DEVELOPMENT OF ISOLATION METHODS OF DIAZEPAM FROM BIOLOGICAL FLUIDS
TSSU, Pharmaceutical and Toxicological Chemistry; TSSU, Department of Pharmacognosy and Botanic; Tbilisi Medical Teaching University “Hippocrates“ Department of Pharmacy,
Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.79-82
Developed optimal conditions of isolation of Diazepam from biological fluids (blood and urine) by liquid-liquid and solid-phase extraction. In the case of liquid – liquid extraction, full isolation of Diazepam from bio – objects is provided by the system of solvents Hexane : Methanol (9:1), with a pH value of 9. On the basis of experiments, the optimal volume of sample model for solid – phase extraction from biological fluids was established; moreover the buffer, the column conditioning circumstances, the eluating solvents and their correlation were initiated.
24. JIKIA G., MUSELIANI T., PETRIASHVILI E.
COMBINED DETERMINATION OF PESTICIDES IN THE RIVER LOPOTA
Iv.beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.82-87
The rural population in order to increase productivity and combat pests, mainly pesticides and fertilizers uses, which are to be introduced without any norms. All of this leads to pesticides accumulate in water, soil and bottom sediments, and then going on to involve them in the river of the living systems in the food chain, in addition to accumulated at the plant vegetative parts, and fruit, which actually affects human health.
25. NADAREISHVILI D., KIPIANI G., ZENAISHVILI S., NIKOLAISHVILI M.
THE INFLUENCE OF HIGH FREQUENCY EPM AND THE CORRECTION OF PARODONTITIS WITH PHYTO-PREPARATION “STEPALOL-E” IN THE EXPERIMENT
Dentistry service of “Aversi Clinic”, Iv. Beritashvili Center of Experimental Biomedicine,
Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.87-91
The application of the phyto-preparation “Stepalol E” in the experiment shows anti-inflammatory, regenerative, antioxidant effects that are more evident when the immune system is low than in intact animals. According to pathomorphology studies, in the action of “Stepalol E” the activation of vascular reacytion is the most essential that favors the transport of phagocytes, oxygen and nutrients as well as elimination of ultimate metabolites.
26. 1PESHKOVA T., 1GIORGADZE E., 1UCHAVA L., 2KAMASHIDZE K.
PREVALENCE RATES OF SUBCLINICAL HYPOTHYROIDISM IN PREGNANT GEORGIAN WOMEN
1 National Institute of Endocrinology, Tbilisi, Georgia; 2 Batumi Maternity House, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.91-96
Subclinical hypothyroidism (SCH) has been reported to be associated with adverse pregnancy outcomes. Aim of this study was to determine the geography specific second trimester reference interval for thyroid-stimulating hormone (TSH), along with the prevalence of SCH in pregnant Georgian women. This was a retrospective cross-sectional study. We used data from medical records during pregnancy and birth of 2876 pregnant women, who were admitted to Batumi Maternity House for routine prenatal examination, including TSH screening.
The second trimester reference interval for TSH, calculated from thyroid dysfunction risk free pregnant women and based on 2.5th and 97.5th percentiles was determined to be 0.21–4.1 mIU/L. The prevalence of SCH evaluated using derived trimester-specific reference interval, reference interval provided by manufacturer for non-pregnant adults and ATA recommended standard was 10.9%, 5.8% and 23.2%, respectively. The prevalence was significantly (more than 2 times) greater in case when ATA recommended standard was used and almost 2 times less in case when reference interval provided by manufacturer was used.
These results highlight the importance of determination of laboratory- and geography specific reference interval in order to avoid misclassification and improve management of thyroid dysfunction in Georgian pregnant women. Considering the immense impact that maternal thyroid dysfunction has on maternal and fetal outcomes, universal screening of pregnant women for SCH should be considered.
27. PESHKOVA T., GIORGADZE E., CHACHIBAIA N.
MATERNAL SUBCLINICAL HYPOTHYROIDISM AND INTELLECTUAL DEVELOPMENT OF OFFSPRING
National Institute of Endocrinology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.96-100
Background - The impact of maternal subclinical hypothyroidism (SCH) on the intellectual development of the offspring is not entirely clear. Objective - To evaluate the intelligence quotient (IQ) of children whose mothers had been diagnosed with SCH prenatally by routine screening and compare with matched controls using a case-control study.
Methods - IQ scores were compared among 8-9 years old offspring of 23 control mothers whose thyroid stimulating hormone (TSH) concentration was <4.1 mIU/L - 97.5th percentile of a cohort of 2876 mothers at 16-18 weeks gestation, of 22 untreated hypothyroid women whose TSH was between 4.1-5.0 mUI/L and of 23 levothyroxine treated women whose TSH concentration was 5-10mIU/L.
Results - Mean (SD) IQs for each group of children were 103.3 (13.4), 97.4(11.56) and 105.5 (13.5). The mean and SD of IQs of the children of the control group and treated hypothyroid mothers were significantly higher than those of the children of untreated hypothyroid women. The percentage of children with IQs >2SD below the control mean was two times frequently in children with untreated mothers than in control group.
Conclusion – Our study size and design prevents us from making statements on correlation between maternal SCH and IQ of the offspring, however our data demonstrates the significance of the potential impact of routine prenatal screening for public healthcare.
28. CHEISHVILI J., ZARNADZE I., ZARNADZE SH.
REDUCE CHILD MORTALITY
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.100-102
Reduce Child Mortality by two thirds is the main goal of Millennium (MDG Goal 4). Child mortality – a key indicator for child well-being – reflects a country’s social and economic development. It tells of children’s access to basic health interventions such as vaccinations, medical treatment and adequate nutrition.
29. KHAZARADZE K., JAPARIDZE N.
THE IMPACT OF TOURISM ON THE ENVIRONMENT IN MOUNTAINOUS
REGIONS OF GEORGIA
Ministry of Labour, Health and Social Affairs of Georgia;
Georgian State Teaching University of Physical Education and Sport, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.102-105
The results ofthe statistical analysisof tourism developmentin Georgiafrom 2005-2014 are represented. Prospectsand problems of themountainousregionswere analyzed.The ways of solvingthe main problems were represented. Two basicproblems were identified- management oflandfillsandqualification of the personnelin the tourism sector.
30. GVINERIA I., ZHURULI M., SAAKADZE V., ONIANI T., GHVABERIDZE O.
ENVIROENMENTAL CONTAMINATION AND PUBLIC HEALTH PROBLEMS IN ZESTAFONI AND SURROUNDING AREA
N. Makhviladze S/R Institute of Labour Medicine and Ecology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.105-108
Statistical analysis of data estimated the health conditions of Zestafoni and surrounding territory living population, the structure of common diseases. Among them, so called “indicative” diseases related to environmental contamination are much more impotent.
Disbalance of microelements was determined in bio substrates (hair) of residents. Especially, the high content of Mn, Sr, Ca, and Cl. was observed. Substances such as Se, Br, Zn, Fe and K were in a small amount.
31. JAVAKHADZE R., SHUBLADZE KH., KHATIASHVILI N., CHIGOGIDZE KH., GHVABERIDZE O.
WORK ENVIRONMENT AND OCCUPATIONAL HEALTH, NEW
APPROACHES AND PRINCIPLES
N. Makhviladze Research Institute of Labor Medicine and Ecology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.108-111
Labor is the main social factor and existence source of any society. Health maintenance of workers is the most important function. “Global Plan of Action on Workers’ Health 2008-2017” is a occupational health issues of WHO strategy, according to which Georgia is to develop a national policy for the protection of worker’s health. In recent years, developments in Georgia, serious economic and financial conditions had influence on employment health protection system. As a result of this is the state long-term program ” Preventing of Occupational Diseases”, which is being held in the Research Institute of Labor Medicine and Ecology”. It represents one of the state strategic directions, which is to ensure the occupational health and safety of working population in Georgia.
32. TSKHVEDIANI N., TSIBADZE A., TSARTSIDZE K., KHUTSISHVILI L., JANASHIA K.
DATABASE OF THE HEART RATE VARIABILITY WITH MICROSOFT
ACCESS SOFTWARE SUPPORT
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.111-114
The goal of the work was a creation of the heart rate variability indices database by means of Microsoft Access. A pilot research was made in 42 healthy persons and 30 patients with essential hypertension. In 42 healthy persons 77 records totally and one record in every patient with essential hypertension were made.
It is reasonable to create database by use of Microsoft Access for a perfect analysis of the heart rate variability Holter’s short records (30 minutes). Final tables of the database allow to reveal specific features of the total group as well as an influence of environmental factors on particular proband on the base of a specific individual reaction.
33. Chitashvili D., korinteli E., Nebieridze N.
The correlation of physical properties and functional changes in highly qualified sportsmen at different stages of training
Ilia State University; The Georgian State Educational University
of Physical Education and Sports, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.114-116
On the basis of the study of the correlation of mechanisms between the physical properties and functional changes in highly qualified sportsmen the combined National team of judoists of Georgia was composed.
34 PRUIDZE N., KHECURIANI R., KIPAROIDZE S., ARABULI M., ORMOTCSADZE G., SANIKIDZE T.
HUMAN AGE- AND SEX-RELATED ALTERATIONS OF RED BLOOD CELLS ANTIOXIDANT ENZYMES ACTIVITY
Tbilisi State Medical University, Department of Normal Anatomy;
Department of Medical Physics and Biophysics, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.116-120
According the data of our investigation, the antioxidant enzymes activity (SOD, CAT) was especially low in young and old age in both sexes. In sexual maturity the activity of CAT dramatically increased as in females also in males; in females this parameter reduced sharply again in period of menopause (45-55 year), whereas in males decreased more gradually. SOD activity does not change in females and strongly increases in mails in period of sexual maturity.
This results documented both age-, sex-related aspects in alterations of RBCs antioxidant enzymes activity. High antioxidant capacity during sexual maturation and its depletion in aging might be the course of development of age-related diseases and protective use of the antioxidants.
35. KVIZHINADZE N.
CHARACTERISTICS OF A HEALTHY LIFESTYLE AMONG ADOLESCENTS
Department of Social and Clinical pharmacy, Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.120-122
The purpose of the study is the formation of a healthy lifestyle among adolescents, which is a complex of measures directed at the underlying socio-hygienic evaluation. The fulfilled investigation confirmed that the situation in the country over the deepest in youth health. The health problems caused by poverty and poor diet-related risk factors, including tobacco and alcohol broad consumption, drug addiction and substance abuse etc. The importance should be given to a healthy lifestyle for the formation of the monitoring, which includes a variety of contingency complex medical and psycho physiological studies, teaching the young generation; Food and leisure time, the organization, the development of hygienic habits.
36. TSIMAKURIDZE M., KHACHAPURIDZE N., ZURASHVILI D.,
TSIMAKURIDZE MAIA, MAISURADZE E.
VOCATIONAL REHABILITATION AND PREVENTION IN OCCUPATIONAL MEDICINE
TSMU, Department of Environmental Health and Occupational Medicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.122-124
The capacity of work of patients in occupational illness is characterized by heaviness and clinical form of illness. Also it depends on the work nature. The solution of expertise problems requires taking into consideration the importance of pathological factors, which distinguishes it from similar form of the disease which has unprofessional character. Prevention system of occupational illness needs to be planned in stages and be tightly related to hygiene measures and medical-biological procedures. Preventing procedures have to be accomplished considering the importance of production technology, also the characteristics of occupational hazards and other risk factors, which determine the terms of work production. These procedures include comprehensive reorganization of all major production procedures. The principal place belongs to pre-placement and periodic medical examination in the group of medical-biological preventive procedures.
37. TATOYAN M.
EMBRYONAL ERITROPOIESES IN SPLEEN
Department of Histology, Cytology and Embriology, YSMU after M. Heratsi,
Laboratory of Cell Biology, Institute of Molecular Biology of NAS, Yerevan, Armenia
J. Experimental and Clinical Medicine, 2015, 4, pp.124-128
The spleen is formed at the end of the 1st month of an embryogenesis and intensively grows up to the 90th days of an embryogenesis, the volume of an eritropoieses in tissue of a spleen is very great by 45 days of prenatal development of swine, however considerably less to that in a liver.
38. METSKHVARISHVILI G., KALANDARISHVILI L., KORINTELI I., PAGAVA K.
BACTERIOPHAGE THERAPY IN NEONATAL SEPSIS IN
PREMATURE BABIES
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 4, pp.128-133
There was studies the clinical efficacy of bacteriophage therapy in neonatal sepsis in premature babies. 40 neonates were under observation. 20 of them received standart therapy plus bacteriophage per os, other 20 – placebo instead of bacteriophage. In the basic group 4 patients died, in control group - 6. The statistically significant improvement of the integrated indicator of the common state of the organism (expressed in scores) was revealed. The received data indicate on the purposefullness of the inclusion of the bacteriophage therapy in the complex treatment of sepsis in premature neonates.