J.EXPERIMENTAL & CLINICAL MEDICINE
2014, ¹ 3
1. M.GIORGOBIANI, B.ZURASHVILI, L.BAKURIDZE, AL. BAKURIDZE, J. PUTKARADZE
GLOBAL ENVIRONMENTAL POLLUTION AND PERSPECTIVES OF USE MODERN NUTRITIONAL SUPPLEMENTS FOR STRENGTHENING THE BODY’S ADAPTIVE MECHANISMS
TSMU, Faculty of Public health, Batumi Shota Rustaveli State University, Supreme Council of the Autonomous Republic of Adjara, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.10-12
Authors presented and analyzed perspectives of use biologically active nutritional supplements “Geomin ", “Pitomin" and “Geomin forte”. Considering their own and their foreign colleagues research data, these supplements, with purpose of enhancing the body's adaptive mechanisms, could be prescribed together with traditional drugs for treatment, rehabilitation and prevention of diseases caused by ecological factors.
2. F. JAFARIDZE , M. BAQRADZE, N. SHONIA
DETERMINATION OF FLUORIDE CONTENT OF DRINKING WATER IN THE REGION OF A JARA
TSMU Department of Orthopedic Stomatology and Maxillo-Facial Surgery;
Batumi, Shota Rustaveli State Universiti Department of Stomatology, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.12-16
The main dental diseases (dental caries and periodontal tissue diseases) due to their wide distribution is not only a medical but also a social problem. Our research is aimed at, as this disease is an important factor - determine the fluorine content in the drinking water of the region's communities. The findings showed that the optimal amount of fluoride ions in drinking water in this region compared to the control measures should be used to lower the caries fluorine-containing products.
3.N.CHAGANAVA, G.LEKISHVILI, B.ARZIANI
THE EFFECTS OF AIR POLLUTION ON THE PHENOL CONTENT IN BLACKBERRY LEAVES
TSMU, Departament of Medical Chemistry, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.16-18
Foliar total phenol concentrations were determined in blackberry (Rubus caesuis) leaves collected from Bakuriani, Batumi and Zestaphoni supposedly affected by various forms of atmospheric pollutants. There is revealed a certain correlation between the phenol content and air pollution extent this allows for application of phenolic compounds as bioindicators.
4. L.ZARDIASHVILI, M. JOKHADZE, J.KUCHUKHIDZE, D.CHINCHARADZE,
EVALUATION OF POLYPHENOLS CONTENT AND CYTOTOXIC ACTIVITIES OF BUDS OF BETULA MEDWEDEWII GROWING IN GEORGIA
Tbilisi State Medical University, Departament of Pharmacognosy and Botany, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.18-21
The cytotoxic effects in plants are mainly due to the presence of phenolic compounds such as flavonoids, phenolic acids and tannins. The cytotoxic potential of different fractions (respective organic fractions of n-hexane, chloroform and dichloromethane) of methanol extract of Betula medwedewii was evaluated on Hela (ephitheloid cervix carcinoma, human) cell lines using 96-well tissue culture microplate WST-1 reagent assays. The methanol crude extract and dichloromethane showed strong activities in all antioxidant assays and contained a high level of total phenolic content. It was observed that the level of hydrophilic phenolic content was higher than that of hydrophobics. Among those organic solvent fractions, n-hexane and chloroform fractions exhibited signiﬁcant activities due to the highest level of total phenolic content.
5. MAIA TSIMAKURIDZE, N. KHACHAPURIDZE, D. ZURASHVILI, M. TSIMAKURIDZE,
E. MAISURADZE, T. BAQRADZE
PECULIARITIES OF HEALTH EFFECTS OF THE WORKERS AFTER STOPPING THE CONTACT WITH THE INDUSTRIAL HAZARDS
TSMU, Department of Environmental Health and Occupational Medicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.21-24
Authors investigated the peculiarities of the health effects of the workers after stopping the contact with the industrial hazards. Examination of the patients showed deterioration of the changes of clinical and paraclinical findings. Authors ascertained that pathological process progressed after stopping the contact with the industrial hazards. Later changes of the cardiovascular, digestive and osteoarticular systems were added to the revealed pathology.
6. Z. GIORGAIA
ECOLOGICAL-ECONOMIC ASSESSMENT OF MOUNTAIN FORESTS OF GEORGIA (ON THE EXAMPLE OF THE SAMTSKHE-JAVAKHETI REGION)
St. Andreu – Called Georgian University of the Patriarchy of Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.24-27
The article proves the necessity to determine the total economic value of natural resources, particularly forests, which are estimated protective and rekreatsionnye functions of these resources. For example, the forests of the Samtskhe-Javakheti region determined the value of ecosystem functions, services and there are given the results of the study on the subject.
7. A.ISAKADZE, M. NONIASHVILI
PREVALENCE OF CHRONIC NON-INFECTIOUS DISORDERS IN GENERAL PRACTICE
Tbilisi State Medical University, Departament of Therapy, Tbilisi, Georgy
J. Experimental and Clinical Medicine, 2014, 3, pp.27-30
Aim. The study of prevalence of carbohydrate metabolism disorders (CHMD) in females.
Materials and methods. A representative sample of 20-59 year-old female population of the city of Tbilisi was examined using age-specific standardized index, WHO tests and criteria.
Results. CHMD occurred rather frequently. Tolerance to glucose was abnormal in 50% of the examinees. Diabetes mellitus affected 20-29 year-old women 4 times more frequently than poor glucose tolerance. An opposite trend was observed for 40-49 year-old women.
Conclusion. Relevant prophylactic measures are required for female Tbilisi population.
8. K.KHAZARADZE, E.ALAVERDASHVILI, KH.BARKALAYA, M.TSITSKISHVILI,
OBJECTIVE ASSESSMENT OF THE IMPACT OF ENVIRONMENTAL FACTORS ON HEALTH OF THE POPULATION
J. Experimental and Clinical Medicine, 2014, 3, pp.30-32
In operation, based on statistical analysis of the data measured during onco-epidemiological situation. Made an attempt to estimate the total economic loss caused by damage to population health from the contamination of the environment. The calculation is based on the amount of damage from disease, disability and mortality.
9. K. KURASHVILI, K. SOKHADZE, SH. ZARNADZE, T. DARSANIA
BASIC ASPECTS OF NOURISHMENT ORGANIZATION IN PUBLIC SCHOOLS
TSMU, Department of Preventive Medicine and Environmental Health – trend of Nutritional and Age Medicine, Ministry of Agriculture of Georgia, Food National Agency, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.32-35
In 2014 in the scale of Georgia has been implemented inspection of public school refreshment rooms and cafeteria/dining halls that exposed some discrepancies: strict part of school cafeteria/dining halls requires repair-and-renovation works (damage control) and maintenance of sanitary-hygiene norms for storage and realization of foodstuffs.
Nourishment of public school children does not satisfy minimal requirements. In many schools are installed automatic machines for selling foodstuffs and drinkables that constitute a menace for children’s health.
School nourishment should be implemented by the agency that complies with the Georgian current legislation about healthcare, education and safety of foodstuffs and its execution/implementation should be controlled by the competent authorities.
10. R.KVERENCHKHILADZE, L.BAKRADZE, G.KVERENCHKHILADZE
INFLUENCE OF WORKING CONDITIONS OF THE METALLURGICAL INDUSTRY WORKERS ON A FUNCTIONAL CONDITION OF THEIR CARDIOVASCULAR SYSTEM
The Direction of Environmental Health and Occupational Medicine of Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.35-37
The functional state cardiovascular system of metallurgical enterprises hot professions workers are studied in age aspect by means of a pulsometriya and control of arterial pressure. Relationship of cause and effect between intensity of thermal loading of an organism and the revealed changes is established. Changes of pulse in dynamics are characterized by age and seasonal features. Sharply expressed changes of arterial pressure in dynamics of the working day aren't found. The received results allowed to develop a complex of sanitation measures.
11. JAVAKHADZE R., ARABIDZE M., KHATIASHVILI N, QVATADZE M., RIJINASHVILI M., KHVADAGIANI K., CHIGOGIDZE KH.G, SHUBLADZE KH., GVABERIDZE O.
LABOR AND HEALTH OF HOSPITALS STAFF AS A PROBLEM OF LABOR MEDICINE
N. Makhviladze Research Institute of Labor Medicine and Ecology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.37-41
The authors studied labor conditions, health state and life quality of surgery medical staff of three hospitals in Tbilisi through hygienic, clinical and psychometric methods and questionnaire. It is proved that nowadays surgery medical staff is characterized by low quality of life and health; their life style could not be considered healthy because of intensive work load that prevents from rational schedules of work, rest and diet. Complex prescription and recommendations are given to improve quality of medical professionals.
12. PAGAVA K, TODUA M
ENVIRONMENTAL PEDIATRICS: CHALLENGES AND POSSIBLE RESPONSES
Tbilisi State Medical University; Tbilisi Ivane Javakhishvili State University, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.41-44
In the work there is given analysis of the literature concerning environmental pediatrics. There is underlined, that in order to diminish the level of environmental pathology there are necessary to carry out special investigations, to develop policy in this area, to raise the awareness of medical professionals and the whole society (incl. children and adolescents) on this problem.
13. T. SHISHNIASHVILI, N. SULADZE
EARLY DIAGNOSTICS OF LEAD ACCUMULATION AND DISORDERS OF MINERAL METABOLISM IN YOUNG CHILDREN BASED ON ANALYSIS OF HAIR AND DENTAL HARD TISSUES
Tbilisi State Medical University, Department of children and Adolescents dentistry. Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.44-47
In recent years air pollution with heavy metals has significantly increased. Environmental factors have a great influence on human health, as well as on dental status in young children.
The aim of our study was to determine the toxic heavy metal (lead) in biosubstrates (hair and dental hard tissues). We studied 28 children aged of 3-4 years living in ecologically different conditions. To determine the content of lead in hair and dental hard tissues X-ray fluorescence spectrometry method was used.
According to our data, air pollution with lead significantly affect the dental status of young children, in particular, on the mineralization of dental hard tissues.
At the same time the use of biosubstrates (hair and teeth) as an indicator of environmental pollution allow us to determine the risk-factors of dental diseases and to develop and implement effective prevention programs.
14. N.ANTELAVA, N.GONGADZE, M.OKUJAVA, K.BAKURIDZE, K.PACHKORIA, M.GHONGHADZE
SUB-ACUTE TOXICITY OF CHAKHATY, KVIRIKE AND BESHUMI MUD - SULPHIDE SILT PELOIDS DISTRIBUTED IN ADJARA REGION
Tbilisi State Medical University, Department of Medical
Pharmacology and Pharmacotherapy, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.47-50
Peloidotherapy is well known for a long time. Depending from mud structure and composition they can have broad variety of biological activities. The goal of our research was assessment of sub-acute toxicity of Chakhaty mud, Kvirike mud and Beshumi mud - sulphide silt peloids distributed in Adjara region. The study was provided in white mice. Application of mud was carried out daily during 14 days. The integral parameters, morphological data, mass of internal organs and biochemical indexes were assessed. Obtained results confirmed safety of local application of studded mud and absence of resorbtive action. The provided experiments confirmed that all mud can be recommended for external application in medical practice and cosmetology.
15. N.NEMSITSVERIDZE, I.TSURTSUMIA T.KILASONIA, T.PANCHULIDZE, N.APTSIAURI
CONFLICT MANAGEMENT IN THE PHARMACY
Tbilisi State Medical University, Department of Social and Clinical Pharmacy,Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.50-52
The ability of manager to provide qualified management of conflict situations is considered as one of the major problems of administrative management. The aim of current work was an investigation of conflict situations in the pharmacies of Tbilisi through the survey for pharmacists and consumers (patients). To conduct the study, a questionnaire for pharmacists and consumers was developed. In total, 20 respondents were asked. For the credibility, anonymous survey was conducted. Has been proved that conflict situations in the pharmacies were related to the field of consumer services: long queue, delayed services, as well as discontent with the quality and prices of medicines. It should be noted that a big number of conflict situations is associated with healthcare reform, introduction of prescriptions for the drugs containing psychotropic substances. According to the conducted studies it can be proved that unfortunately, pharmaceutical services require further professional and psychological improvement, which in turn will help pharmacists to minimize conflict situations with the consumers.
16. MAISASHVILI M., JOKHADZE M.,. KUCHUKHIDZE.J, CHINCHARADZE D.
QUANTITATIVE ANALYSIS OF AGINOZIDE FROM THE FLOWERS OF ALLIUM ROTUNDUM L. BY LC/MS
Tbilisi State Medical University, Department of Botany and Pharmacognosy, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.52-55
There are 37 species of the genus Allium found in Georgia. Allium rotundum L. is one of the richest in biologically active compounds, out of which steroidal saponins are the most important.
The goal of this research was the quantitative determination of a steroidal saponin – aginozide by LC/MS, obtained from the flowers of the Allium rotundum L.
Has been developed qualitative and quantitative determination methods by HPLC and LC/MS. Has been calculated the maximum content of aginozide (2.2 mg/g) in the aerial parts of the Allium rotundum and has been determined optimal conditions for extraction of steroidal saponines.
17. A.K. BAZIKYAN
Some QUESTIONS of oncological morbidity of URBAN AND RURAL POPULATION in the Republic of Armenia
V.Fanarjyan National Oncological Center, Yerevan, Armenia
J. Experimental and Clinical Medicine, 2014, 3, pp.55-59
The oncological morbidity, its dynamics and structure have been studied among the urban and rural population of the Republic of Armenia in 2000-2009. It was shown that the frequency of morbidity both in urban and rural regions has a reliable increase compared to 2000's, àt the same time, it has a jump-like behaviour in urban and gradually – in rural. It has been established also that in the oncological morbidity structure in all years predominated the urban population.
18. CHIKVILADZE D., GACHECHILADZE KH., MIKELADZE M., METREVELI D.
COMPARATIVE STUDY OF INTESTINAL MICROFLORA, ISOLATED FROM PRACTICALLY HAELTHY PERSONS
Tbilisi State Medical University, Department of Microbiology and Immunology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.59-62
Microbiological study revealed high oceurrence of dysbacteriosis with the decreased amount of E.coli (79,6%) and the presence of E.coli hemolytic forms (73,9%). Rather often the alevated contend of E. coli with decreased fermentative properties was noted (51,5%). In all cases E. coli with decreased biochemical activity had hemolytic activity, which was accompanied by the deficiency of bifidobacteria (82,3% of cases) and the combined deficiency of lactic acid bacteria and bifidobacteria (76,3% of cases).
19. M. ELOSHVILI, I. MCHEDLISHVILI
INVESTIGATION OF ETIOLOGICAL STRUCTURE OF BACTERIAL MENINGITIS IN CHILDREN
National Center for Disease Control and Public Health
Public Health Department, Tbilisi State Medical University, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.62-64
Etiological structure of suspect cases of Bacterial Meningitis among children under 5, hospitalized in Iashvili Children Hospital was investigated. Out of 424 infected children 27 cases (6.4%) were laboratory confirmed by using bacteriological testing, latex agglutination reaction. Main etiologic factors were H. Influenzae, type b (48%), N.Meningitidis (26%) and S.Pneuomoniae (26%).
20. K.GAMBASHIDZE, N.BEZHITASHVILI, N.PKHALADZE, T.AZALADZE,
ANTI-CANCER EFFICACY OF BACTERIOPHAGES AND BACTERIAL PHAGE LYSATES IN VIVO EXPERIMENTAL STUDIES
Tbilisi State Medical University, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.64-67
Bacteriophages have been used successfully to cure bacterial infections. However, the novel observations suggest that they can affect immunological processes and may be crucial against cancer growth. Investigations have shown that bacterial phage lysates are characterized by high immunogenicity. The active component in the lysate – supposedly lipopolysaccharide (LPS), has been shown to stimulate the host humoral immune response and induce the release of various cytokines.
In the presented study the results of experimental investigations carried out on lab mice with Ehrlich carcinoma subjected to vaccinations with bacteriophages and phage lysates of E.coli and comparative analysis of the anti-cancer treatment efficacy have been suggested. Investigations have shown that antitumor efficacy of vaccinations is well expressed in E.coli phage lysate vaccinated mice. Administration of pure phage suspensions had no significant treatment effects.
21. RIGVAVA S.A1, BUBASHVILI M.E.1, NADAREISHVILI L.S.2, HOYLE N.S.2, GOGIASHVILI D.A. 1, NATIDZE M.M., ALAVIDZE Z.I. 3, NIJARADZE D.R. 2
VALUE OF THE ASSESSMENT OF THE IMMUNE RESPONSE AGAINST SOME BACTERIAL INFECTIONS
1G.Eliava Institute of Bacteriophage, Microbiology and Virology, Tbilisi, Georgia; 2G.Eliava International Phage Therapy Center, Tbilisi; 3Georgian-American phagotherapy Center, Tbilisi
J. Experimental and Clinical Medicine, 2014, 3, pp.67-72
Serological testing for various bacterial pathogens was performed in 324 patients, among which, 48 were tested for mixed bacterial infections. 85 samples of blood serum were tested for fungal (Candidal) infections. A significantly large number of patients (52,5%) were found to have clinically relevant levels of Staphylococcal α-toxin and somatic antigen.
The levels of Staphylococcal antibacterial and antitoxic antibodies were also studied before and after bacteriophage therapy. It was found that the titer of antibodies toward the pathogenic bacteria were reduced during phage therapy. Subjective clinical improvement correlated with the decrease in antibody titers in many cases.
Based on our data we can conclude that complex serological studies are useful investigations not only allow as a method of diagnostics but also a useful tool in the selection of treatment tactics in mixed bacterial infections. Our data gives a strong foundation to continue study in this direction, in order to further confirm the opinions and clinical correlations we present here.
22. SHISHNIASHVILI T., SULADZE T. , MAKHVILADZE M.
INFLUENCE OF INTESTINAL DYSBIOSIS ON DENTAL DISEASES IN CHILDHOOD
Tbilisi State Medical University, Department of Children and Adolescents Therapeutic Dentistry; “Diagnozi 90” Bacteriophage Diagnostic Center, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.72-75
According to conducted study we can conclude that there is an influence of intestinal dysbiosis on the process of endogenous absorption of calcium into the oral hard tissue. Process of active progressive caries characterized by decalcification (demineralization), is mostly based on reduced concentration of minerals in hard tissues, in terms of disturbed delivery of endogenous calcium.
According to our study, we can conclude that during intestinal dysbiosis the degree of tooth hard tissue demineralization increases, what can predispose to caries formation. It was found that the gastrointestinal flora is in a positive correlation with the spread of dental caries: the higher the degree of intestinal dysbiosis, the higher the number of teeth damaged by caries. It also affirms that there is connection between somatic and dental diseases and brings up necessity of complex correction of health.
23. GOGICHADZE G., GOGICHADZE T.
POSSIBLE CORRELATION BETWEEN BACTERIA AND MALIGNANT NEOPLASMS
Tbilisi State Medical University, Department of Microbiology and Immunology, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.75-77
Recently, a definite correlation between bacterial toxins and the possible development of cancer has been found. It needs to be noted here that the cellular and molecular mechanisms by which bacteria contribute to cancer still remain fully understood. In this article, we shall attempt to focus on exactly the presumptive cellular and sub-cellular mechanisms through which some toxins are likely to induce tumor conversion of a normal cells. As rigidity of leucocytes’ membranes is higher, it is possible that during destruction of erythrocytes by hemolytic membranotoxins, reversible damages of plasma membranes (pores of definite size and number) can be formed in leucocytes (or in other cells), which can promote the process of adhesion of somatic cells, leading further to the process of fusion in somatic cells and the formation of first precancerous and then cancerous cell.
24. CHITASHVILI D., KORINTELI E.
THE PECULIARITIES OF APPROXIMATE STANDARDS OF PHYSICAL PREPARATIONAND FUNCTIOMAL CHARACTERISTICS OF 7-8 YEAR OLD CHILDREN OF SPORTS SCHOOL
Ilia State University, Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.77-79
This paper presents the existing data on the functional and physical preparedness of 7-8 year old boys and girls. According to these data the enrollment in the sports group of general physical preparation takes place. In accordance with the training periods the rechecking and the correction of the data occur three times a year.
25. KOCHARYAN S.P.
determination OF THE intervals of statistical values
of homocysteine concentration in blood OF GROOP of healthy individuals and describtion of their limits of pathological changes
Yerevan State Medical University, Armenia
J. Experimental and Clinical Medicine, 2014, 3, pp.79-82
The content of homocysteine in the blood of 100 healthy persons was studied in this work using a normal Gaussian distribution. The following characteristics of homocysteine are determined: the average value (mathematical expectation), standard deviation, and confidence interval, in other words, the reference values of homocysteine concentration in the blood.
Methods of determination: determination of the concentration of homocysteine in the blood serum was carried out on the biochemical analyzers that are common in clinical diagnostic laboratories.
26. ZARNADZE SH.
MILITARY NUTRITION AND EUROPEAN DEVELOPMENT IN GEORGIA
Tbilisi State Medical University
Nutrition and Aging Medicine Direction, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.82-85
Historical examples demonstrate that a failure to supply adequate nutrition to armies inevitably leads to disaster; however, innovative measures to overcome difficulties in feeding reap benefits, and save lives. Severely wounded military personnel are likely to lose a significant amount of their muscle mass, in spite of the best medical care. The role of nutrition in wound healing will be considered in relation to the current paucity of data to inform clinical dietetic practices in trauma medicine. The history of military nutrition are many examples in history that illustrate the impact of feeding provision on the success of military campaigns.
27. ZARNADZE I., KITOVANI D., LOMTADZE L., KAJRISHVILI M.
INFORMATIONAL SYSTEM AND DAE BASES IN GENERAL HOSPITALS
Tbilisi State Medical University, Health Care Management, Policy and Economy Direction, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.85-87
Health Care informational system and date bases is the quality indicators of medical organizations in all steps or fields of Medical Services. Results of research demonstrate: the 76% of medical workers haven’t skills working in internet, or medical services haven’t internet resources. More 39% reed the new information in profile books, 24% found the information in internet and others in other resources, scientific journal and etc.
Implementation of new system needs the professionals, educational end counseling system, financial and technical resources.
Effectiveness of Good informational system is the good outcome, in clinical and organizational activity.
28. ZARNADZE SH., ZARNADZE I.
Tbilisi State Medical University,
Nutrition and Aging Medicine Direction, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.87-89
The future of sports nutrition will dictate that we collectively will have to have a higher standard of care and education for counseling , whether individually or in groups. The integration of many different disciplines (physiology, metabolism, psychology, etc.) will become a minimum mandatory set of disciplines for any aspiring sports nutritionist.
29. ALANIA M., SALASHVILI K., SAGAREISHVILI T., KAVTARADZE N., SUTIASHVILI M., ANELI J.
PECUALIRITY OF DISTRIBUTION OF PHENOLIC COMPOUNDS IN PLANTS OF GEORGIAN FLORA
Tbilisi State Medical University, Iovel Kutateladze Institute of Pharmacochemistry,
J. Experimental and Clinical Medicine, 2014, 3, pp.89-92
The effect of environmental factors on the accumulation of flavonoids in plants from Georgian Flora as presented. Propitious influence on the content of flavonoids for plant groups of Imereti and surrouding regions is noted. The role of flavonoids in plant protection is disscused.
The results obtained make it possible to carry out a focused search for biologically active compounds.
30. MELIA L., MOSIDZE B., KINTRAIA N., SULUKHIA R.
URGENT SIMULTANEOUS OPERATIONS IN GYNECOLOGY
J. Experimental and Clinical Medicine, 2014, 3, pp.92-96
Number of the patients being in need of urgent surgical measures is being steadily increased giving simultaneous rise to the number of urgent surgical interference. According to the data of WHO, number of patients with simultaneous pathologies is from 20 to 30% and in the much less cases they undergo fluent surgical services. We executed 113 operations on genitalia simultaneously with appendectomy. Ages of the patients were from 17 to 43. All the operations were provided in the conditions of multi-field medical center. Pathomorphological confirmation of appendicitis took place in all cases. Congestive appendicitis was diagnosed in 74 cases, phlegmonous – in 27 cases, and phlegmonous-sphacelous – in 12 cases. In the first place gynecology stage, and secondly – the surgical one was provided. Simultaneous operations in case of appendicitis under the conditions of urgent surgery shall be provided with strict regard to the instructions. Careful intraoperative inspection of the abdominal cavity shall be imperative condition.
31. ALADASHVILI L., KHETSURIANI R., SHUKAKIDZE A., ARABULI M., TOPURIA D., TCHLIKADZE N.
CHANGES OF PHYSICAL PARAMETERS OF NORMOCYTESAFTER EXTRACORPOREAL USE OF LASER
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.96-98
The studies were made on the erythrocytes (normocytes ) of the rabbits with the influence of helium-neon laser. It was detected, that after the usage of extracorporeal laser, takes place growth of normocytes, but their physical parameters are reduced, especially after 6 hours. This must have reactive character and it is connected with the micropolarization phenomenon. It should be conditioned by the change of cell’s internal medium, which changes intensity of metabolism and functional intensity of erythrocytes, which itself provides positive therapeutic effect.
32. KOCHLAMAZASHVILI A., NASKIDASHVILI M.
Union of Georgia-Foreign Countries Friendship International Society Preventive Cardiologic Room, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.98-100
The term psychological stenocardia was introduced by Academician Avtandil Kotchlamazashvili and implies a syndrome of such stenocardic pain when pathological morphological substrate from heart coronary arteries is excluded and a leading role in its origin belongs to nervous system.
From May 2010 until October 2012 inclusive, we have observed 100 patients (29 women and 71 men) of psychological stenocardia, whose age was between 18-35 years. And according to the developed scheme - based on the interviews focused on the disease history, there was underlined the point that was more important for the psychological development of stenocardia.
Based on the conducted studies there may be drawn the following conclusions:
1. Psychological stenocardia at a young age has been formed against the general neurosis condition and it is a peculiar expression of neurosis that demands accurate clinical differentiation of organic stenocardia.
2. In 70% of cases of psychological development of stenocardia is caused by lasting psycho-emotional stress, and in 32% -by acute nervous stress.
3. Timely diagnosis of heart muscle infarction, appropriate treatment and proper orientation of forecast are of great importance for the prevention of psychological stenocardia.
33. KHOTIVARI N.
RISK-FACTORS OF ENDOMETRIAL HYPERPLASIA IN PERIMENOPAUSAL PERIOD
Tbilisi State Medical University, Obstetric Ginecological Departament, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.100-103
It is important to reveal timely endometrial hyperplasia in perimenopausal period for prevention of endometrial cancer. For this purpose we analise 75 personal medical records (PHR) during 2012-2013 retrospectively in our hospital. We choose patients for this aim according to the perimenopausal age and hystologically and ultrasonografically detected endometrial hiperplasia. Our studies show that risk-factors of endometrial hyperplasia is the age between 45-48 years, accompanying gynecological deseases-leiomioma, endometriosis, chronic inflamattory deseases, nullipairit and endocrinological disorders such as obesity, diabetes, thyroid gland deseases. According to our results for prevention of endometrial hyperplasia it is necessary to perform diagnostic procedures and appropriate correction timely at reproductive age.
34. LOBZHANIDZE N., CHAVCHANIDZE N., GIORGOBIANI T., KURDADZE E.
CARDIOTOXIC EFFECTS OF ACUTE INTOXICATION WITH AMITRIPTYLINE
The direction of clinical toxicology (Department of critical Medicine),
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.103-107
The cardiotoxic action of amitriptyline is important prognostic factor in the clinical course of intoxication with amitriptyline.
According to L.Kostomarov cardiotoxic effect of amitriptyline is revealed with cardiac rhythm and conduction disturbances, hemodynamic instability and severe deterioration of tissue perfusion caused by exotoxic shock.
In the article electrocardiographic effects of amitriptyline intoxication are described and treatment options are discussed in two different clinical cases.
35. MATOSHVILI M., TOPHURIA D., KATSITADZE A., ALADASHVILI L.
PSORIASIS IN CHILDREN: STUDY OF 112 PATIENTS FROM GEORGIA
Tbilisi State Medical University, Department of Dermatology and Venereology, Department of Human Normal Anatomy
J. Experimental and Clinical Medicine, 2014, 3, pp.107-109
Psoriasis is a chronic autoimmune disease that affects approximately 1–3% of the world’s population. It may occur at any age and childhood psoriasis is a relatively common entity. It has been estimated that in 10% of the patients the onset of the disease is before the age of 10 years and in 2% before 2 years. The aim of our study was to examine the patterns of psoriasis in our pediatric patients, the age of onset, the sex prevalence and the severity of the disease. Between 2007 and 2013, information was collected about all children diagnosed with psoriasis in the department of dermatology and venereology at Tbilisi State Medical University.
36. CHICHINADZE K., NIKOLAISHVILI M., JIKIA G., MUSELIANI T., KOPTONASHVILI L.
DETERMINATION OF ANIMALS’ DOMINANCE BEFORE DEVELOPING A SOCIAL HIERARCHY BY “OPEN FIELD” METHOD
I.Beritashvili Center of Experimental Biomedicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.109-113
Base on our data, we can conclude, that aggressive rats are characterized by high anxiety, than nonaggressive rats, which is revealed by boluses, and urination, the time spent in grooming, low rate of translocation and length of movement from central circle. We would say that processes in animals brain activate metabolism of those biologically active agents that enhance the dependence to hazard, increase emotional condition and determine changes of behavioral acts as well s high adaptation of rats to different stressors
37. CHICHINADZE K., NIKOLAISHVILI M., JIKIA G., MUSELIANI T., KOPTONASHVILI L.
DETERMINATION OF WORKING CAPACITY AND ENDURANCE IN VERY AGGRESSIVE AND LESS AGGRESSIVE RATS IN EARLY ONTOGENESIS
Beritashvili Center of Eexperimental Biomedicine, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.113-115
Environmental pollution due to technical progress, defective technology of a number of industry sectors, is reflected in human life. Increase in aggressiveness inside population as well as in national matters is detected [9,10]. aggressiology has been separated as an independent scientific discipline for a long time . Aggressiveness as a behavioral act, is determined motivationally, determined genetically and includes a number of biologically active agents. Aggressiveness is directly or indirectly related to the activity of appropriate genes . Owing to total escalation in aggressiveness in the world, determination of its causes and mechanisms is becoming extremely topical. As it is realized, aggressiveness could be caused by permanently changeable stress factors [6,10]. At present, a phenomenon of aggressiveness, its causes and preventive ways are less studied [2,4]. In the recent years an intensive study has been carried out in order to find out mechanisms that are characterized for aggressiveness e.g. to determine emotional condition of a subject. Emotion is specific objective changes, is characterized by vitality that is expressed by biochemical, electrophysiological, motor functions [3,5]. Hence, the aim of our topic is to determine endurance and working capacity before the development of hierarchical status in two-month old rats that were selected by Yumatov method as more aggressive and less aggressive rats.
38. GVINERIA I., SAAKADZE V., JURULI M, ONIANI T., GVABERIDZE O.
INDUSTRIAL CHEMICALS AND HEALTH RISKS AT THE AUTOMOBILE TECHNICAL SERVICE STATIONS
N.Makhviladze S/R Institute of Labour health and Ecology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.115-117
The harmful influence of chemicals on workers health was studied in Tbilisi automobile technical service stations. Revealed that most of technicians are exposed to harmful chemicals. Recommendations for the prevention of occupational diseases have been elaborated.
39. NIKOLAISHVILI M., GOGUA M., FRANCHUKI Q., ZENAISVILI S.
TREATMENT BY GRAPE SEED AND CORIANDER OIL OF PATIENTS WITH PERIODONTITIS
D.Aghmashenebeli Tbilisi University of Georgia, I. Beritashvili Biomedicine centre Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.117-119
Oil extracted from Saferavi breed grape seeds by cold pressure and coriander oil in case of periodontitis, causes normalization of oral cavity enzymes action, inhibition of oral cavity inflammatory processes and at last their suppression. Exactly unique properties of oil became cure initiating and periodontitis starting stage stopping agent.
40. NIKOLAISHVILI M., BERIASHVILI S., ZENAISVILI S.
THYROID DYSFUNCTION AND ORAL MUCOSA MINERALIZATION IN TEENAGERS
D.Aghmashenebeli Tbilisi University of Georgia, I. Beritashvili Biomedicine centre, Tbilisi
J. Experimental and Clinical Medicine, 2014, 3, pp.119-121
A new absorption line on the oral mucosa spectra is not observed in teenagers with thyroid dysfunction, but there are some significant qualitative and quantitative changes noted, indicating to decrease in the mineral component concentration of the oral mucosa. Saliva can be considered as a biological fluid, exceptional qualities of which contribute to maintaining of the mineral components of homeostasis in the oral cavity. Literature data and our clinical study results allow us to conclude that in planning stomatological, treating and preventive measures the characteristic changes in teenagers’ thyroid dysfunction must be taken into consideration.
41. Tskhovrebadze N.P., Tskhovrebadze I.P., Khorbaladze M.G.,
Assessment of Actual Nutrition of students of TSMU
TSMU, Department of Preventive Medicine and Environmental Health, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2014, 3, pp.121-125
Actual nutrition of students of TSMU of Georgia has been studied, adequacy of consumption of main nutrients has been assessed, the reasons of nutritional deficiency and excess nutrition have been determined and appropriate recommendations for improving the quality of nutrition have been developed.
Analysis of the results indicates the disturbance of balancing, consumption of high-calorie foods, deficiency of vitamins. Correction of the above mentioned can be done by public education about healthy lifestyle, particularly with implementation of the healthy eating principles.