EXPERIMENTAL & CLINICAL MEDICINE
2007, ¹ 1
EFFECTIVENESS OF THE UNIFICARED PROGRAM FOR PROPHYLAXIS OF SUPPURATIVE SKIN DISEASES AMONG THE WORKERS OF THE RAILWAY AND TRANSPORT SYSTEM OF GEORGIA
J. Experimental and Clinical Medicine, 2007, 1, pp. 9-11.
Polyclinic of Railway Junction, Medical Service of the Railway Department of Georgia
The carried out research estimated the effectiveness of the unificated program for the prophylaxis of pyodermia among the workers of the railway and transport system of Georgia. The observation was held at the car-building and electric-train building plants.
It has been estimated that using the above-mentioned unificated program at the plants will reduce pyodermia diseases, and working abilities of the workers will increase.
2. KUPREISHVILI T., SHANAVA K., SANIKIDZE T., METREVELI D.
CORRECTION OF RATS OXIDATIVE METABOLISM DURING THYREOECTOMY
J. Experimental and Clinical Medicine, 2007, 1, pp. 11-14.
Tbilisi State Medical University, Georgia
The aim of the study was to establish changes in oxidative metabolism of rat liver and myocardium during experimental hypothyroidism and to correct these changes. For the correction of oxidative stress during thyroidectomy we used the herbal medicine “Ologocrin”, revealing antioxidative capacities.
During experimental thyroidectomy in rats the oxidative metabolism of liver and myocardium is disordered, the generators of reactive oxygen species are accumulated, lipid peroxidation and oxidative stress were revealed.
For effective correction of oxidative metabolism during hypothyreosis, the use of antioxidants combined with replacement therapy (L- thyroxine) is recommended.
3. MURADOV Kh., SADIKHOVA G., ALIYEVA I.
OPTIMIZATION OF DIAGNOSIS AND PROGNOSTICATION OF PERIPHERAL PRIMITIVE NEUROECTODERMAL TUMOR (PNET) OF BONE
J. Experimental and Clinical Medicine, 2007, 1, pp. 14-19.
Department of Histology, Embryology and Cytology, Azerbaijan Medical University, Baku
During the last years, on the basis of classical morphology data and modern methods of investigation it has been determined a group of poorly differentiated small cell tumors of the bone marrow called “primitive neuroectodermal tumor” (PNET), which most frequently occur in children and juveniles. The purpose of our investigation is to optimize the early diagnosis and prognostication of these pathologies, using modern methods of investigation.
4. SHULAIA T., KILADZE N., BABILASHVILI I.
MESOTHERAPY IN TREATMENT OF ALOPECIA AREATA
J. Experimental and Clinical Medicine, 2007, 1, pp. 19-22.
Tbilisi State Medical University, Department of Dermato-Venerology;
Center of Dermatology and Aesthetic Medicine “Marjani 21”
Alopecia areata is a common form of non-scarring alopecia which appears equally in males and females of any age. It affects about 1% of the population. The disorder is usually characterized by limited alopecic patches on the scalp. More severe forms may affect the entire scalp (alopecia totalis) or body (alopecia universalis). In the trail were included 21 patients, 11-35 years old, with different extent of alopecia areata on the head and face. 12 patients had been unsuccessfully treated before during several months with topical sensitizers, all others were untreated. In all cases was used the mesotherapeutic method. Injections of nicotinic acid, vitamine C, pentoxiffiline, trace elements –Zn, Se, placentex were conducted twice a week, totally 8 times, then once a week 4 times and after - once a month. The course of treatment took 28 weeks. Injections were done on the whole face and/or head despite of the affected sites. In all cases treatment was successful and no exacerbations or side effects were noted within its whole duration.
Mesotherapy with above-mentioned preparations and regimen is effective for inducing hair regrowth, and may be widely used in common treatment of alopecia areata.
5. KIPSHIDZE N., KAKAURIDZE N., KABISASHVILI S.
RELATION OF LIPID SPECTER INDICES WITH ARTERIAL HYPERTENSION, CONSIDERING RELIGIOUS FACTORS
J. Experimental and Clinical Medicine, 2007, 1, pp. 22-25.
National Center of Therapy – Clinical & Experimental Institute for Therapy, Tbilisi
To date, arterial hypertension still remains one of the main noninfectious pandemics determining the structure of cardiovascular diseases and high percent of mortality caused by complications. From this point of view, lately more and more attention is attracted by the influence of religiosity on cardiovascular diseases and arterial hypertension.
The aim of the study is to determine relations between lipid specter indexes with arterial hypertension, considering religiosity, in the Georgian population. It was found out that believers with arterial hypertension have reliably low indexes of triglycerides, unlike unbelievers. Total cholesterol and CH-LDL in these two groups are of equal level (though still exceed the levels taken as standard), type of feeding and tolerance toward psychoemotional stresses playing a great role. Presumably, religiosity exerts positive influence on these factors particularly. It’s possible that a study of the religiosity factor will reveal significant reserve abilities in the issue of solving problems of cardiovascular diseases.
ANTERIOR PRETRACHEAL APPROACH IN SURGICAL TREATMENT OF CERVICAL SPINAL STENOSES
J. Experimental and Clinical Medicine, 2007, 1, pp. 25-30.
With the purpose of definition of the efficacy of anterior pretracheal approach application during decompressive-stabilizing operations for surgical treatment of cervical spinal stenoses, in the 1994-2006 period surgical interventions were performed in 162 patients. A significant improvement (expression of radiculo-myelopathy decreased by 3-4 gradations) was achieved in 34% of the patients, improvement (neurological manifestations decreased by 1-2 gradations) – in 51% of the patients, and no changes were noted in the clinical presentation of 9%, deterioration was noted in 6%. Anterior pretracheal approach allows to execute necessary decompression, creates enough place for manipulations in the operative wound, and so makes possible to achieve good results in postoperative period.
THE RESULTS OF STUDIES OF CALCILATE BIOLOGICAL EFFECT ON THE ORGANISM
J. Experimental and Clinical Medicine, 2007, 1, pp. 30-33.
Department of Orthopedic Stomatology, Tbilisi State Medical University, Georgia
Were studied some indices (rates) of biological effect of calcilate (albuminous–mineral agent of animal origin) on the organism, with the purpose to establish the possibility of its use in medical practice, particularly stomatology (dentistry), for therapy and prophylaxis of periodontitis. In subacute and chronic experiment, while feeding white rats with diets containing calcilate, there were not detected any toxic influences of probationer preparation (specimen). Biochemical indices of blood serum in all the groups of animals remained within standards. The use of probationer preparation separately, as well as together with casein provoked structural changes and disturbances of metabolic processes neither in the organs, nor in their parenchyma and stroma. Results of the studies testify preservation of the organs integrity. Intake of calcilate by laboratory white rats does not change general condition of animals and does not give occasion to argue about its adverse effect (influence). The results of the researches testify complete safety of calcilate for a living organism. It is possible to use calcilate with the purpose of studying its ability to correct definite shifts in human being’s organism, in particular, for therapy and prophylaxis of periodontitis.
8. TSISKARISHVILI N., TSISKARISHVILI N.
SOME ONCOGENIC MARKERS OF HUMAN PAPILLOMA VIRUS INFECTED WOMEN
J. Experimental and Clinical Medicine, 2007, 1, pp. 33-35.
I.Javakhishvili Tbilisi State University, Therapy-Diagnostic Center, Tbilisi, Georgia
Clinical-morphological characteristic was given to 15 patients infected by the human papilloma virus. With the purpose of determination of some oncogenic markers the method of immuno-enzymatic analysis was applied to measure cancer embryonic antigen concentration. The increased level of activity of this antigen was found out in 29.9% of the patients. Inclusion of specified analysis in the complex examination allowed to reveal the patients representing the cervix uterus cancer development risk-group.
9. BENDELIANI TS., KILADZE N., IASASHVILI N.
COMPLEX TREATMENT OF SKIN SIGNS IN METABOLIC SYNDROME WITH MESOTHERAPY METHOD
J. Experimental and Clinical Medicine, 2007, 1, pp. 35-37.
Tbilisi State Medical University, Department of Dermato-Venerology;
Center of Dermatology and Aesthetic Medicine “Marjani 21”
In the present work were studied the possibilities of mesotherapy (channel or tracer technique) in 23 patients with metabolic syndrome. All of them were females aged 45-55 in premenopausal or menopausal period accompanied with a decrease of estrogen level and disorders of lipid metabolism. In all cases the duration of skin elements existence was less than one year. 5 of the patients had xanthelasma, 11 - plate xanthoma, and 7 - abdominal type of adiposity. Topical treatment was provided, using special mesotherapy technique – trace or channel - with intradermal injections of lipostabil (phosphatidilcholin) and 2% procaine. Injections were done directly into the diseased sites once a week, totally 10 procedures. For improvement of blood supply, and in order to receive better lipolytic effect, 12 patients were additionally injected with nicotinic acid.
To the end of the treatment, in the majority of the patients (19) the elements dissolved, in 4 cases improvement obvious - the elements size was significantly decreased, they became flatter.
Conclusion. the method of mesotherapy with local injections directly into the diseased sites is a potent and safe method supporting fast recovery or improvement of skin signs in patients with metabolic syndrome.
10. MURADOV Kh., ALIYEVA I., SADIGOVA G.
OPTIMIZATION OF DIAGNOSIS AND PROGNOSTICATION OF OSTEOSARCOMA
J. Experimental and Clinical Medicine, 2007, 1, pp. 37-44.
Department of Histology, Embryology and Cytology, Azerbaijan Medical University, Baku
Osteosarcoma represents one of the most frequently occurring bone tumors.
Since the treatment of this pathology includes a heavy radiation and medicamental load as well as disabling capital operations, timely diagnosis of osteosarcoma by the electron microscopic, immunohistochemical, flow cytometry diagnostic methods became the main purpose of our research.
11. BEZARASHVILI B., GURGENIDZE G.
VALUES OF CORTISOL-RESISTANT FRACTION OF PERIPHERAL BLOOD LYMPHOCYTES IN ASTHMATIC CHILDREN
J. Experimental and Clinical Medicine, 2007, 1, pp. 44-46.
Diagnostic-Treatment Center “House of Health”;
Institute of Medical Biotechnology, Tbilisi, Georgia
46 children with well-documented asthma (26 atopic and 20 nonatopic patients) and 22 healthy volunteers were examined for peripheral blood lymphocyte cortisol-resistent fraction (LCRF) content, using an lymphocytotoxic test with the following trypan blue dye exclusion method in order to determine specific immunologic triggers of bronchial hyperreactivity formation. According to the results of the study, it was revealed statistically significant increase in absolute, as well as percentage values of LCRF in non atopic asthamatic patients as compared with analogous data obtained from healthy children. In contrast, no difference was demonstrated in the groups of atopic asthmatics and healthy volunteers. Comparison of values characterizing LCRF content in atopic and non-atopic asthmatics revealed statistically significant increase of only % (and not - absolute) values of LCRF in non atopic asthmatic children. These immunological disorders were hardly associated with disease severity.
12. E. KHADIROV, V. SHADLINSKI, U. GABUNIA, N. GOISHVILI
FEATURES OF VASCULARIZATION AND MICROVESICULAR DENSITY IN CANCER-LINEAL RATS DURING BREST CANCER DEVELOPMENT
J. Experimental and Clinical Medicine, 2007, 1, pp. 46-49.
Department of Human Anatomy of AMU, Baku, Azerbaijan,
A.Natishvili Institute of Morphology, Tbilisi, Georgia
There was studied vascularization and micro vesicular density in the process of cancer development on 55 cancer lineal (“A” and “C3H”) rats. The following methods were used: anatomical (vascular injection with Indian ink-Gelatin), histological, immunohistochemical (staining with marker of proliferation – Ki67 and marker of angiogenesis – CD31) and morphometric methods.
There was estimated that along with aging, angiogenesis and Micro vesicular Density increases. Vascularization is more intense in high-grade forms of breast cancer than in low-grade forms.
With the grading of breast cancer, the number of recently formed thin vessels increases, but the number of preformed vessels decreases.
13. N.K. CHICHINADZE, E.B. MELIKIDZE
MORPHOLOGICAL CHANGES OF TESTICLE AT THE BACKGROUND
OF PHENOL INTOXICATION
J. Experimental and Clinical Medicine, 2007, 1, pp. 49-51.
A. Natishvili Institute Experimental Morphology, Tbilisi, Georgia
Testicle is the major driving nucleus of a reproduction system. It is known that the male reproduction system of a man is very sensitive to a series of harmful factors, which can result in serious changes in the whole body. Our experimental study was devoted to the problem of the influence of toxic factors on the male reproduction system, namely in our experiments we carried out intoxication of 40 adult male albino rats of 250 g mass each, daily, for 15 days, using phenol vapor. We pursued to determine whether phenol acted as a deregulator of endocrine system or not, whether it could condition the disorder in reproduction system, namely in testicle. On the 16, 30, 45 and 60 days from the beginning of the experiment, we decapitated animals and removed testicles to determine the rate of damage, both morphologically and functionally and simultaneously to determine whether the intoxicated organism is able to mobilize its energetic forces in order to avoid complications connected with the morphological changes in testicle. The obtained data showed that the long-term effect of phenol conditioned the deregulatory changes in testicle, the decrease of number of capillaries, peeling of endotheliocytes, and all the above stated, together – conditioned tissue hypoxia.