J.EXPERIMENTAL & CLINICAL MEDICINE
2015, ¹ 1
1. PLESKANOVSKAYA S., HOJAGELDIEVA A.
ÎN THE MULBERRY TREE’S LIVES (MTL) AND SILK WORM’S (BOMBIX MORE) EXCREMENTS’ (SWE) WATER EXTRACTS IN HEPATO-BILIAR PATHOLOGY PATIENTS’ TREATMENT USING
Scientific research center of State Medical University of Turkmenistan, Ashgabat
J. Experimental and Clinical Medicine, 2015, 1, pp.9-12
Treatment of hepato-biliar pathology stays one of the seriously problem of modern physicians. In spate of the certain successes in this direction more and more cases of ineffective one has appear [9]. During lot of years we are studying therapeutic and immune modulating ability of Mulberry tree’s lives (MTL) and silk worm (Bombix more) excrements’ (SWE) water extracts. It has been shown immunomodulating activity of some fractions of SWE [7,18,19,20], of melanin’s especially [12,17]. Besides, as MTL as SWE has high antibacterial activity in vitro [1]. They can to inhibit migration of rheumatoid arthritis patients blood leucocytes’ [5,16] and immune response of practically healthy persons‘ (PHP) blood leucocytes to soluble tissues antigens of thyroid gland [3,4] in vitro. On the base of great number obtained data the concept of phytoimmunemodulation has been elaborated [12].
The goal of the presenting work was to study the MTL and SWE’s water extracts influence on the PHP, hepatitis-C (HCV) and chronic uncalculous holecystitis (CC) patients’ leucocytes functional activity in vitro and in vivo to dissolve the purpose of ability their using in the hepato-biliar pathology treatment.
2. N.VEPKHVADZE, N.TSKHOVREBADZE, I.TSKHOVREBADZE, M. KHORBALADZE,
T. KOCHORADZE
ASSESSMENT OF ACTUAL NUTRITION OF POPULATION OF ADJARIAN MOUNTAINOUS REGION OF GEORGIA
TSMU, Department of Preventive Medicine and Environmental Health
J. Experimental and Clinical Medicine, 2015, 1, pp.12-15
Actual nutrition of population of Adjarian Mountainous Region (Keda, Khulo, Shuakhevi districts) of Georgia has been studied, adequacy of consumption of main nutrients (proteins, fats, hydrocarbons, vitamins, macroelements) has been assessed, the reasons of nutritional deficiency and excess nutrition have been determined and appropriate recommendations for improving the quality of nutrition have been developed.
Analysis of the results indicates the disturbance of balancing, consumption of high-calorie foods, deficiency of vitamins and macroelements (P and Ca).
Correction of the above mentioned can be done by education of the population in healthy lifestyle issues in general and particularly in a healthy diet and eating habits.
3. N. GONGADZE, L. GABUNIA, M. GOGOLAURI, M. MIRZIASHVILI, ANNA ARCHVADZE,
MECHANISM OF ACTIONS AND EFFECTS OF ANTIHYPERTENSIVE DRUGS COMBINATIONS
Tbilisi State Medical University, Department of Medical Pharmacology and Pharmacotherapy, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.15-20
Nowadays Hypertension is the most widespread cardiovascular disease, which affects primarily heart, kidney and brain blood vessels. In the same time hypertension increases risks and frequencies of development of coronary disease, hemorrhagic insults as well as cardiac and renal deficiency.
Currently, several effective antihypertensive drugs are available for treating of hypertension. The comprehension of mechanisms of actions, effectiveness, adverse effects and toxicities of antihypertensive drugs permit us to specify a rational treatment by one or more drugs to control hypertension and to minimize unfavorable affects of applied drugs. The treatment of hypertension by combination of two or three agents is the most frequently applied method to reduce blood pressure significantly and to meet the defined goal. Moreover, only drug combination therapy is the method to control hypertension in patients with diabetes or kidney diseases. So, the combination of several classes of antihypertensive agents allows us to get required reduction of blood pressure and to avoid dose -dependent adverse effect of administrated drugs.
4. R. KHETSURIANI, H. SHVANGIRADZE, A. SHUKAKIDZE, L. ALADASHVILI, G.ADAMASHVILI
INFLUENCE OF PLASMAPHERESIS ON THE OUTCOME OF PEDIATRIC PATIENTS WITH SURGICAL SEPSIS IN DIFFERENT AGE GROUPS
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.20-24
Objective: Determination of relative risk of mortality in patients who received plasamapheresis with standard treatment of sepsis, in comparison to patients who received standard treatment alone.
Design: Prospective, randomized controlled clinical trial.
Setting: Intensive Care Unite at Pediatric Clinic of Tbilisi State Medical University.
Patients: Surgical pediatric patients with severe sepsis, septic shock and MODS.
Interventions: 157 patients randomized to receive either standard sepsis treatment or an add-on treatment - plasmapheresis.
Measurments: Mortality rates were detected in plasmapheresis and control groups and relative risk of mortality associated with plasmapheresis were calculated.
Results: Relative risk of mortality in plasmapheresis group was 0.65 (95% CI 0.46-0.93). This represents absolute risk reduction of 19.4% p=0.015. Subsequent investigation showed up statistically significant influence of plasmapheresis on outcome of patients in 1 month – 3 years old age group (absolute risk reduction of 51,8% p=0.003).
Conclusions: Plasmapheresis administration with described technique has an influence on mortality rate of surgical pediatric patients with severe sepsis, especiallyl in infants.
5. K. KHARABADZE, D. KOBESHAVIDZE, T. MACHITADZE
RELATIVE ANALYSIS OF FOLEY CATHETER AND MISOPROSTOL, APPLIED FOR LABOR INDUCTION
Tbilisi State Medical University, LTD “Imedis Clinic”, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.24-27
The goal of research was relative analysis of Foley catheter and misoprostol used for labor induction. We carried out comparison of 2 clinical groups (31 and 40 pregnant women) by maternal and fetal complications (uterine tachysystole, FHR-pathological changes) and also by frequency of operative labor.
The following advantages of Foley catheter were revealed: low cost, easy availability, mechanical nature, minimization of FHR – “pathological” categories and operations of cesarean section.
6. N.EMUKHVARY, E.TSETSKHLADZE, KH. KHIJAKADZE, I. MAMATSASHVILI, R.NAPETVARIDZE
THE RATE OF CARDIOVASCULAR EVENTS IN CAD PATIENTS AFTER SUCCESSFUL PERCUTANEUS CORONARY INTERVENTION
J. Experimental and Clinical Medicine, 2015, 1, pp.27-30
The aim of our study was to detect the relation between the CK-MB elevation and early and late cardiovascular events rate after successful PCI in CAD patients with normal level of CK-MB before PCI.
The study revealas, that significant elevation of CK-MB after PCI is a predictor of early and late cardiovascular events. Moderate elevation of CK-MB is not associated with early and late complications.
7. GABUNIA L., KHETSURIANI SH., GAMKRELIDZE N., VARAZI E.
ETHICAL ISSUES OF CLINICAL TRIAL PHASES
Tbilisi State Medical University, Research Skills Center, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.30-33
Medical progress is based on research that includes studies involving human subjects. The primary purpose of medical research involving human subjects is to understand the causes, development and effects of diseases and improve preventive, diagnostic and therapeutic interventions (methods, procedures, and treatments).
While the primary purpose of medical research is to generate new knowledge, this goal can never take precedence over the rights and interests of individual research subjects.
Important areas of ethics are: informed consent, confidentiality, anonymity.
Development of new drugs begins in the laboratory through biochemical procedures and animal experiments. On this preclinical tests show promise of efficacy and probable safety, human trials can be performed in phases, usually 3, before their approval for marketing. A post marketing fourth phase may be performed the additional purposes. Study design parameters, such as the need for control groups, randomization, and sample sizes, may differ considerably for each of the 3 study phases. 1st phase is preformed on a small number of patients (usually 20 to 30) primarily to determine the drug's safety. Different dosage regimens may be tested to determine the dose that causes minimal adverse effects. Once phase I shows an acceptable safety profile, the drug can be tested in a larger number of patients (usually >100) primarily for efficacy but also for safety.
In this phase, the drug may be compared with a placebo or a current standard treatment in a double-blind method (ie. neither the patient nor the assessing investigator is aware of the type of treatment).
After documenting a statistically significant efficacy of the new drug (usually above placebo), the drug is tried in a larger number (hundreds or thousands) of patients, primarily focused on efficacy while continuing to monitor safety (phase 3).
After marketing of the drug for some years, the manufacturer may choose to perform post marketing clinical trials (phase 4). The objective of the trial may be to compare the drug with other available treatments, to investigate the efficacy and safety of new dosage or combination regimens, or to explore new potential indications for the drug.
8. UKLEBA K., GVETADZE L., KUCHAVA U., DEMURIA L.
THE CHARACTERISTICS OF BRONCHIAL ASTHMA MANAGEMENT AT PRIMARY HEALTHCARE SYSTEM
Akaki Tsereteli State University, Faculty of Health Care, Kutaisi, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.33-37
The objective of our research was to improve the quality of medical service at Primary Medical Care system for patients diseased with bronchial asthma.
The work was based on the audit of medical services provided to patients diseased with bronchial asthma that was conducted at Kutaisi Center of Family Medicine targeting medical map of 65 patients. The data gathering was conducted by the medical records of registered patients, clinical interviews conducted among medics and nurses/paramedics.
The results of conducted audit revealed that the quality of Primary Healthcare Services provided to the patients registered as having bronchial asthma requires improvements: It is necessary to ensure the regular addressing of patients with bronchial asthma, by creating an effective system of secondary visits and its gradual improvement. As the research conducted has revealed the criteria of patient addressing is 75% and it is far from the standard 100%. As for the identification and control of risk factors as the research shows it is 55%. This leads to think that the risk factors of bronchial asthma are not being determined with each and every patient or this data is not being recorded in medical documentation.
As for the usage of methods for examining the stages of asthma it is not reaching the standards and is 75% (p< 0,05). This means that the medical personnel is not using all the equipment available for diagnosing and managing bronchial asthma in order to ensure effective control of the disease. The research has also proved that there are deviations in treatment especially in the controlling therapy. The criteria is 72% (p<0,05) and is below the standard (100%), there are deviations in the length of treatment and its coherence.
It is necessary to establish the effective schemes of asthma treatment in Primary Healthcare System and to conduct trainings for capacity building of respective medical personnel.
It is necessary to share the results of the audit with medical personnel and conduct re-audit in order to check the effectiveness of the measures taken so far.
9. BERIDZE N., CHOMAKHASVHILI Z., ZOSIDZE N.
VARIANTS OF THE LOCATION OF THE BILE TUBULES IN THE
PORTA OF HEPAR
Batumi Shota Rustaveli State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.37-41
The article shous that the typical division of the bile tubules on the right and left branches in our case was revealed in 88.7%, respectively atypical division there was in 11.3%. From this 3.8% of cases was trifurcation of the main trunk of bile tubule, and 7.5% in the case there was right paramedian vein transposition. From trifurcation place of the bile tubule to start of themoved up right paramedian tubule, that is to thearea of transposition, ranges from 0.9 cm to 1.7 cm.
10. K. KHARABADZE, D. KOBESHAVIDZE, T. MACHITADZE
ASSESSMENT OF EFFECTIVENESS OF COMBINED ADMINISTRATION OF FOLEY CATHETER AND MISOPROSTOL
Tbilisi State Medical University, LTD “Imedis Clinic”, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.41-44
The goal of research was to define the effectiveness of labor induction by combined administration of Foley catheter and misoprostol. Two clinical groups were studied. I group contained 32 pregnant women, to whom combined method was applied. 40 pregnant women from II group underwent induction only by misoprostol.
The several advantages of combine method were revealed: application of minimal doses of misoprostol; statistically significant decrease of the frequencies of uterine tachysystole, FHR – “pathological” categories and respectively, operations of cesarean sections.
11. KHETSURIANI R., SHVANGIRADZE H., SHUKAKIDZE A., ADAMASHVILI G., JIKIDZE N., ALADASHVILI L.
INFLUENCE OF PLASMAPHERESIS ON ORGAN DISFUNCTION IN PEDIATRIC PATIENTS WITH SEVERE SURGICAL SEPSIS
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.44-49
Objective: Determination of organ disfunction changes in surgical pediatric patients with severe sepsis who received plasamapheresis with standard treatment, in comparison to patients who received standard treatment alone.
Design: Prospective, randomized controlled clinical trial.
Setting: Intensive Care Unite at Pediatric Clinic of Tbilisi State Medical University.
Patients: Surgical pediatric patients with severe sepsis, septic shock and MODS.
Interventions: 157 patients randomized to receive either standard sepsis treatment or an add-on treatment - plasmapheresis.
Measurements: Determination of PELOD scores and ΔPELOD before and after plasmapheresis procedure (in 24 hours) and in control group at the time of diagnosis estabilishment and after 4 days of standard treatment.
Results: Reduction of organ systems dysfunction severity in general population of patients measured by PELOD score was 18,6% (p=0,012) which was not a rule for each age subgroup of patients. Contrary, each age subgroup of control group showed up increase of PELOD score with overall 19% increase in MODS severity and probability of mortality
Conclusions: Plasmapheresis as add-on to standard treatment resists progression of MODS in pediatric patients of any age group with severe surgical sepsis.
12. EGNATIEVI1 I., TSINTSADZE2 M., FRANCHUK2 K., SHERMADINI2 K., GABUNIA2 F., ABAISHVILI1 N.
SITUATIONAL OVERVIEW OF HIVAIDS IN GEORGIA IN 2014
1David Agmashenebeli University of Georgia; 2Infectious Diseases,
AIDS and Clinical Immunology Research Center. Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.49-54
It is well established that along with improvement of general health condition, the risk for transferring HIV virus is decreasing among the patients who are on antiretroviral treatment and understanding of their status facilitates positive changes in their life style and risky behavior. Therefore, it has to be underlined that diagnosing HIV cases at early stage is critically important for Georgia. Introduction of HIV testing and education of patients on this infection in primary and secondary level health care facilities will improve early detection of HIV/AIDS cases and prevent father spread of the epidemic.
13. KHECURIANI R., ALADASHVILI L., ARABULI M., TOPHURIA D.,
SHVANGIRADZE E., TCHLIKADZE N.
CHANGESIN RATIO OF THE FORMS OF THE ERYTHROCYTES AFTER EXTRACORPOREAL LASER RADIATION ON THE BLOOD
Tbilisi State Medica Universitu, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.54-57
Research is done on the changesin ratio of the forms of the erythrocytes while different amount of extracorporeal irradiation byhelium-neon laser.For this purpose 1 ml blood was taken from normal weight, (1200 gr) grown up shinshila rabbits, that we divided into 9groups andirradiated with 10 vatt helium-neon laser during 0.5-1 minutes. After irradiation blood was injected back to the organism of rabbits. After 2-6 hours from irradiation blood was taken from veins, to study by electronic microscope.
With the research we found out that, while extracorporeal irradiation the ration of the shape of erythrocytes is slightly changed, while during general irradiation, ratio changes takes place, correspondingly changes rheological units and the exchange of oxygen.
The extracorporeal radiation, performed by laser and input of radiated blood back to organism is considered to be a shock therapy from the side of erythrocytes, which promote the defense function of the organism itself.
14. ISAKADZE A., MAKHARADZE T., GVISHIANI M., BULASHVILI D.
EXPEDIENCE OF USING OF LEVOSIMENDAN IN ACUTE AND CHRONIC HEART FAILURE
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.57-62
This article is devoted to expedience of using of levosimendan in acute and chronic heart failure. Levosimendan is a Ca2+-sensitizer cardiotonic drug of nonglycoside origin which exerts its cardiotonic action at the expense of increasing affinity of cardiomyocites contractile proteins to calcium ions, whereas vasodilatory effect of levosimendan is occurred by opening of ATP-sensitive potassium channels. According experimental and clinical study this drug in acute and chronic heart failure improves systolic and diastolic function of the heart, preventive ability regarding remodeling of myocardium and lowering the progressin of heart failure. The inotropic action of levosimendan is produced via stabilization of Ca2+-induced conformation of troponin “C”, while in vasodilatory effect of levosimendan depending on its doses along with potassium channels maybe involved accumulation of CAMP and NO production. It is suggested that levosimendan is a perspective drug in mono-and combine therapy of acute and chronic heart failure.
15. GURGENIDZE M.R. 1, KILADZE M.A. 2, BERIASHVILI Z.A. 3,
DATUASHVILI G.A. 4, TABUCADZE T.U. 5
MINIINVASIVE SURGICAL MANAGEMENT OF CHOLELITHIASIS
1Department of Surgery of High Technology Medical Center–University Clinic; 2Department of Surgery of Georgia-Israel Joint Clinic “Gidmedi”; 3Department of Surgery of Institute of Clinical Oncology; 5Department of Surgery of A.Aladashvili University Clinic; 4Department of Surgery of N.Kipshidze Central University Clinic, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.62-68
The aim of the present study is to analyze outcomes after laparoscopic cholecystectomy (LC) and minilaparotomy cholecystectomy (MC) for gallstone disease and determine the algorithm of treatment for different groups of patients according to the age, severity of disease and comorbid conditions. This is a multicenter retrospective review of 2997 patients who underwent LC or MC between January 1, 2002 and December 31, 2008. The patients were categorized into LC (1479) and MC (1518) groups. When preoperative examination data were not reliable, we performed abdominal wall lifting with the retractors to visualise abdominal cavity with laparoscope during minilaparotomy. There were statistically significant differences in conversion rate (47 LC and 22 MC cases) (P=0.002), mean operating time (76 and 55 minutes in LC and MC, respectively) (P<0.001), mean duration of usage of non-narcotic analgesics postoperatively (1.3 and 1.1 days in LC and MC, respectively) (P<0.001), intra (15 LC and 6 MC cases) (P=0.02) and postoperative complications (96 LC and 72 MC cases) (P=0.05) and in mean hospital stay (1.5 and 1.3 days in LC and MC, respectively) (P<0.001). The difference in outcomes was more significant in elderly and senile patients. The minilaparotomy cholecystectomy is effective, safe and optimal operative procedure. Especially, it is important for countries with lower economic capacity.
16. KIKALISHVILI L., JANDIERI L., RAMISHVILI M., TURMANIDZE T., JANDIERI K.
INDIVIDUAL CHARACTERISTIC OF LOCATION OF THE SUPRARENAL GLANDS
Department of Topographic and Clinical Anatomy, Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.68-72
Individual variability of the location of the suprarenal glands are studied by dissection of 100 adult human corpses. There was determined the shape of the suprarenal gland, syntopy to the hilus of the kidney, to the inferior vera cava, pancreas and the spleen.
According to the obtained making, there was determined that in high location of the suprarenal gland the most part of it was located above the kidney, but its lower part was separated from the hilus of the kidney.
During lower location of the suprarenal gland they descend to the anterior surface of the kidney and are approached to the hilus of the kidney. Most often suprarenal gland had medium location. The left suprarenal gland was located lower than the right and descended more down anteriorly to the kidney and approached the helius of the kidney, than the left suprarenal gland.
17. KHARABADZE K., KOBESHAVIDZE D.
CORRELATIVE RELATION BETWEEN INITIAL PARAMETERS OF FETAL FUNCTIONAL STATE AND OUTCOMES OF LABOR INDUCTION
Tbilisi State Medical University, LTD “Imedis Clinic”, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.72-75
Induction was conducted in two clinical groups. In the I group (40 pregnant women) labor induction performed by oxytocin i/v infusion and in the II group (30 pregnant women) – by misoprostol intravaginal application. In both groups were diagnosed 11 FHR-“pathological” categories followed by urgent operative delivery.
Detailed retrospective analysis revealed the same combination of initial functional fetal markers in all abovementioned pathological cases.
The opinion is expressed that in case of abovementioned combination of pathologically changed initial fetal markers it is preferable to substitute labor induction with urgent operation of cesarean section.
18. KILADZE N., SHULAIA T., ABRAHAMOVYCH L.
CLINICAL-DERMATOSCOPIC DIAGNOSTICS OF BENIGN PIGMENTAL NEOPLASMS IN CHILDREN
Tbilisi State Medical University, Dermatology Dep.; Medical Center “Marjani”, Tbilisi; Lviv State Medical University, Depart. of out-patient, family medicine and dermato-venerology
J. Experimental and Clinical Medicine, 2015, 1, pp.75-78
With increasing incidence of malignant melanoma in childhood and adolescence, it’s late diagnosis and poor prognosis the great importance has the differential diagnosis of clinical and morphological manifestations of benign and pre-malignant variants nevi. The use of dermatoscopy in the evaluation and diagnosis of pigmented lesions has increased during the last decades thus it makes possible to define a number of specific morphological structures, gives the valuable information for their assessment, makes the differentiation more reliable.
In the presented investigation were studied the specific dermatoscopic criteria of pigmented lesions in 103 children and adolescence and described the characteristic peculiarities of dermatoscopic pattern in different melanocytic nevi.
19. JAPARIDZE SH., LOMIDZE L., KEKELIDZE I.
TONZILGON APPLICATION FOR THE TREATMENT OF CHRONIC TONSILLITIS AND AFTER TONSILLECTOMY
Department of Otorhinolaryngology Tbilisi State Medical University, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.78-82
Studies have shown that monotherapy with tonsilgon after tonsillectomy and adenoidal-tonsillectomy accompanied by a decrease of cases of postoperative complications and accelerated repair processes.
20. CHANTURIA Z., ERIASHVILI V., CHUMBURIDZE T., NEMSITSVERIDZE N.
THE RELATIONSHIP OF GPP AND ISO. INTERNATIONAL EXPERIENCE AND ESPECIALLY IN GEORGIA
Tbilisi State Medical University, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.82-85
Pharmacy outside of the experience of the development of the system, observed that the introduction of national standards and the quality control systems.
Georgia in the pharmaceutical sector is characterized by peculiar features. During the year, the pharmaceutical sector in Georgia and mainly focused on the urgent problems of intense reform, including privatization of drug production and supply areas. The current practice requires a change of direction pruduktsa and supplier-oriented. Georgia's reform and development phase is necessary to develop a better future concept of pharmaceutical practice.
Therefore, if the ISO 9000 standard requirements in most countries of the world is considered as the initial stage for the introduction of GPP national standard, it is advisable to practice again in Georgia in the field of national values, which are reflected in the legislative motkhovnebshi, which is mandatory for the development of coordinated stakeholder interests.
21. GHIRDALADZE D., ABASHIDZE M., KIRTAVA T.
ESSENTIAL THROMBCYTHEMIA DIAGNOSIS, DIFFERENTIAL DIAGNOSIS, TREATMENT
Institute of Hematology and Transfusiology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.85-90
In the past 5 years there has been acceleration the number of patients with essential trombocythemia (ET) in the whole world, including Georgia.
Diagnosis of ET may be verified when there is an unexplained, persistent and stabile thrombocytosis (platelet count more then 450,0-600,0×109); marrow aspirate showing hypercelularity in cresing number of megakaryocytes and big clusters of trombocytes; trephinebiopsy showing severe (or moderate) hyperplasia of megakaryocytes line. Myelofibrosis don,t present (MF-O) or fibrosis is not more then MF-1 and in 50-57% of all cases cytogenetycaly may be present mutation of JAK-2 gen V617F.
22. BERIDZE L., KATSITADZE T., EBANOIDZE T., KORSANTIA N.
SAFE AND EFFECTIVE TOPICAL TREATMENT OF ATOPIC DERMATITIS IN CHILDREN
Batumi Republic Clinical Hospital, LTD “Spa House”,
Research National Center for Skin and Venereal Diseases, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.90-92
We studied 20 patients with AD. The age ranged from 3 month to 4 year, the female : male ratio was 5:5. The severity of AD was determined by the objective score of AD (SCORAD) index and dichotomized according to SCORAD values as follows: moderate (15-40) and severe >40. The first group we treated with 1% hydrocortisone cream during 5 days it was applied locale on the eruptions. The second group patients were applied on 1 % pimecrolimus cream during 5 days on the eruptions and Stelatopia emollient cream on the whole body during 1 month. The results of our study reveal that the therapeutic efficacy of 1% pimecrolimus was equivalent to 1% hydrocortisone treatment. These results clearly demonstrate that 1% pimecrolimus cream can be an effective alternative therapeutic agent in cases where steroid treatment is not safe due to its adverse effects. Stelatopia emollient cream reduces skin dryness and frequency of flare-up and improves quality of life. To sum up 1% pimecrolimus cream in combination with Stelatopia emollient is safe and effective topical treatment for AD.
23. GHIRDALADZE D., KIRTAVA T.
HOMOZYGOUS THALASSEMIA AND PREGNANCY – THE FIRST CASE IN GEORGIA
Institute of Hematology and Transfusiology, Tbilisi, Georgia
J. Experimental and Clinical Medicine, 2015, 1, pp.92-95
Today there are 10 patients with homozygous thalassemia aged 16 to 30 years who are treated at the Institute of Hematology and Transfusiology. Only four of them are women. Three women due to ovarian hemosiderosis show amenorrhea and consequently lack of reproductive function.
Only one patient who was treated by chelatotherapy since childhood, got pregnant spontaneously. Pregnancy managed by transfusions and chelatotherapy successfully completed and delivered a healthy newborn.